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  • Aarnio, MikkoUppsala universitet,Anestesiologi och intensivvård (author)

Visualization of painful inflammation in patients with pain after traumatic ankle sprain using [(11)C]-D-deprenyl PET/CT.

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Walter de Gruyter,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-333782
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333782URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:229126847URI
  • https://doi.org/10.1016/j.sjpain.2017.10.008DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BACKGROUND AND AIMS: Positron emission tomography (PET) with the radioligand [(11)C]-D-deprenyl has shown increased signal at location of pain in patients with rheumatoid arthritis and chronic whiplash injury. The binding site of [(11)C]-D-deprenyl in peripheral tissues is suggested to be mitochondrial monoamine oxidase in cells engaged in post-traumatic inflammation and tissue repair processes. The association between [(11)C]-D-deprenyl uptake and the transition from acute to chronic pain remain unknown. Further imaging studies of musculoskeletal pain at the molecular level would benefit from establishing a clinical model in a common and well-defined injury in otherwise healthy and drug-naïve subjects. The aim of this study was to investigate if [(11)C]-D-deprenyl uptake would be acutely elevated in unilateral ankle sprain and if tracer uptake would be reduced as a function of healing, and correlated with pain localizations and pain experience.METHODS: Eight otherwise healthy patients with unilateral ankle sprain were recruited at the emergency department. All underwent [(11)C]-D-deprenyl PET/CT in the acute phase, at one month and 6-14 months after injury.RESULTS: Acute [(11)C]-D-deprenyl uptake at the injury site was a factor of 10.7 (range 2.9-37.3) higher than the intact ankle. During healing, [(11)C]-D-deprenyl uptake decreased, but did not normalize until after 11 months. Patients experiencing persistent pain had prolonged [(11)C]-D-deprenyl uptake in painful locations.CONCLUSIONS AND IMPLICATIONS: The data provide further support that [(11)C]-D-deprenyl PET can visualize, quantify and follow processes in peripheral tissue that may relate to soft tissue injuries, inflammation and associated nociceptive signaling. Such an objective correlate would represent a progress in pain research, as well as in clinical pain diagnostics and management.

Subject headings and genre

  • Ankle injuries
  • Carbon-11
  • Deprenyl
  • Inflammation
  • PET
  • Pain

Added entries (persons, corporate bodies, meetings, titles ...)

  • Appel, LieuweUppsala universitet,Radiologi(Swepub:uu)lap02157 (author)
  • Fredriksson, MatsKarolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden(Swepub:uu)matsfred (author)
  • Gordh, TorstenUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)torsgord (author)
  • Wolf, OlofUppsala universitet,Ortopedi(Swepub:uu)olowo902 (author)
  • Sörensen, JensUppsala universitet,Radiologi(Swepub:uu)jenssore (author)
  • Eriksson, Måns,1986-Uppsala universitet,Statistiska institutionen(Swepub:uu)maner971 (author)
  • Peterson, Magnus,1966-Uppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)mapet227 (author)
  • Linnman, ClasHarvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol, Boston, MA USA (author)
  • Thulin, M (author)
  • Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Related titles

  • In:Scandinavian Journal of Pain: Walter de Gruyter17:1, s. 418-4241877-88601877-8879

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