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Visualization of pa...
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Aarnio, MikkoUppsala universitet,Anestesiologi och intensivvård
(author)
Visualization of painful inflammation in patients with pain after traumatic ankle sprain using [(11)C]-D-deprenyl PET/CT.
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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Walter de Gruyter,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-333782
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333782URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:229126847URI
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https://doi.org/10.1016/j.sjpain.2017.10.008DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND AND AIMS: Positron emission tomography (PET) with the radioligand [(11)C]-D-deprenyl has shown increased signal at location of pain in patients with rheumatoid arthritis and chronic whiplash injury. The binding site of [(11)C]-D-deprenyl in peripheral tissues is suggested to be mitochondrial monoamine oxidase in cells engaged in post-traumatic inflammation and tissue repair processes. The association between [(11)C]-D-deprenyl uptake and the transition from acute to chronic pain remain unknown. Further imaging studies of musculoskeletal pain at the molecular level would benefit from establishing a clinical model in a common and well-defined injury in otherwise healthy and drug-naïve subjects. The aim of this study was to investigate if [(11)C]-D-deprenyl uptake would be acutely elevated in unilateral ankle sprain and if tracer uptake would be reduced as a function of healing, and correlated with pain localizations and pain experience.METHODS: Eight otherwise healthy patients with unilateral ankle sprain were recruited at the emergency department. All underwent [(11)C]-D-deprenyl PET/CT in the acute phase, at one month and 6-14 months after injury.RESULTS: Acute [(11)C]-D-deprenyl uptake at the injury site was a factor of 10.7 (range 2.9-37.3) higher than the intact ankle. During healing, [(11)C]-D-deprenyl uptake decreased, but did not normalize until after 11 months. Patients experiencing persistent pain had prolonged [(11)C]-D-deprenyl uptake in painful locations.CONCLUSIONS AND IMPLICATIONS: The data provide further support that [(11)C]-D-deprenyl PET can visualize, quantify and follow processes in peripheral tissue that may relate to soft tissue injuries, inflammation and associated nociceptive signaling. Such an objective correlate would represent a progress in pain research, as well as in clinical pain diagnostics and management.
Subject headings and genre
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Ankle injuries
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Carbon-11
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Deprenyl
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Inflammation
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PET
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Pain
Added entries (persons, corporate bodies, meetings, titles ...)
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Appel, LieuweUppsala universitet,Radiologi(Swepub:uu)lap02157
(author)
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Fredriksson, MatsKarolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden(Swepub:uu)matsfred
(author)
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Gordh, TorstenUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)torsgord
(author)
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Wolf, OlofUppsala universitet,Ortopedi(Swepub:uu)olowo902
(author)
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Sörensen, JensUppsala universitet,Radiologi(Swepub:uu)jenssore
(author)
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Eriksson, Måns,1986-Uppsala universitet,Statistiska institutionen(Swepub:uu)maner971
(author)
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Peterson, Magnus,1966-Uppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)mapet227
(author)
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Linnman, ClasHarvard Med Sch, Boston Childrens Hosp, Dept Anesthesiol, Boston, MA USA
(author)
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Thulin, M
(author)
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Uppsala universitetAnestesiologi och intensivvård
(creator_code:org_t)
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In:Scandinavian Journal of Pain: Walter de Gruyter17:1, s. 418-4241877-88601877-8879
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