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Low-Dose Aspirin Di...
Low-Dose Aspirin Discontinuation and Risk of Cardiovascular Events : A Swedish Nationwide, Population-Based Cohort Study
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- Sundström, Johan (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Sweden
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- Hedberg, Jakob, 1972- (author)
- Uppsala universitet,Gastrointestinalkirurgi,Uppsala University, Sweden
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- Thuresson, Marcus (author)
- Statisticon AB, Uppsala, Sweden.
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- Aarskog, Pernilla (author)
- AstraZeneca Nord Balt, Sodertalje, Sweden.
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- Johannesen, Kasper (author)
- Linköpings universitet,Avdelningen för hälso- och sjukvårdsanalys,Medicinska fakulteten
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- Oldgren, Jonas, 1964- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Sweden
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2017
- 2017
- English.
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In: Circulation. - : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7322 .- 1524-4539. ; 136:13, s. 1183-1192
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- BACKGROUND: There are increasing concerns about risks associated with aspirin discontinuation in the absence of major surgery or bleeding. We investigated whether long-term low-dose aspirin discontinuation and treatment gaps increase the risk of cardiovascular events.METHODS: We performed a cohort study of 601 527 users of low-dose aspirin for primary or secondary prevention in the Swedish prescription register between 2005 and 2009 who were >40 years of age, were free from previous cancer, and had >= 80% adherence during the first observed year of treatment. Cardiovascular events were identified with the Swedish inpatient and cause-of-death registers. The first 3 months after a major bleeding or surgical procedure were excluded from the time at risk.RESULTS: During a median of 3.0 years of follow-up, 62 690 cardiovascular events occurred. Patients who discontinued aspirin had a higher rate of cardiovascular events than those who continued (multivariable-adjusted hazard ratio, 1.37; 95% confidence interval, 1.34-1.41), corresponding to an additional cardiovascular event observed per year in 1 of every 74 patients who discontinue aspirin. The risk increased shortly after discontinuation and did not appear to diminish over time.CONCLUSIONS: In long-term users, discontinuation of low-dose aspirin in the absence of major surgery or bleeding was associated with a >30% increased risk of cardiovascular events. Adherence to low-dose aspirin treatment in the absence of major surgery or bleeding is likely an important treatment goal.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- aspirin
- cohort studies
- primary prevention
- secondary prevention
Publication and Content Type
- ref (subject category)
- art (subject category)
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