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Pooled analysis of ...
Pooled analysis of active cigarette smoking and invasive breast cancer risk in 14 cohort studies.
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2016-12-28
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Oxford University Press (OUP),2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-337248
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-337248URI
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https://doi.org/10.1093/ije/dyw288DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136264707URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: The 2014 US Surgeon General's report noted research gaps necessary to determine a causal relationship between active cigarette smoking and invasive breast cancer risk, including the role of alcohol consumption, timing of exposure, modification by menopausal status and heterogeneity by oestrogen receptor (ER) status.Methods: To address these issues, we pooled data from 14 cohort studies contributing 934 681 participants (36 060 invasive breast cancer cases). Cox proportional hazard regression models were used to calculate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs).Results: Smoking duration before first birth was positively associated with risk ( P -value for trend = 2 × 10 -7 ) with the highest HR for initiation >10 years before first birth (HR = 1.18, CI 1.12-1.24). Effect modification by current alcohol consumption was evident for the association with smoking duration before first birth ( P -value=2×10 -4 ); compared with never-smoking non-drinkers, initiation >10 years before first birth was associated with risk in every category of alcohol intake, including non-drinkers (HR = 1.15, CI 1.04-1.28) and those who consumed at least three drinks per day (1.85, 1.55-2.21). Associations with smoking before first birth were limited to risk of ER+ breast cancer ( P -value for homogeneity=3×10 -3 ). Other smoking timing and duration characteristics were associated with risk even after controlling for alcohol, but were not associated with risk in non-drinkers. Effect modification by menopause was not evident.Conclusions: Smoking, particularly if initiated before first birth, was modestly associated with ER+ breast cancer risk that was not confounded by amount of adult alcohol intake. Possible links with breast cancer provide additional motivation for young women to not initiate smoking.
Subject headings and genre
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alcohol
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breast cancer
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tobacco smoking
Added entries (persons, corporate bodies, meetings, titles ...)
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Carter, Brian D
(author)
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Brinton, Louise A
(author)
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Falk, Roni T
(author)
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Gram, Inger T
(author)
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Luo, Juhua
(author)
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Milne, Roger L
(author)
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Nyante, Sarah J
(author)
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Weiderpass, ElisabeteKarolinska Institutet
(author)
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Beane Freeman, Laura E
(author)
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Sandler, Dale P
(author)
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Robien, Kim
(author)
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Anderson, Kristin E
(author)
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Giles, Graham G
(author)
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Chen, Wendy Y
(author)
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Feskanich, Diane
(author)
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Braaten, Tonje
(author)
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Isaacs, Claudine
(author)
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Butler, Lesley M
(author)
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Koh, Woon-Puay
(author)
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Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi(Swepub:uu)alwol516
(author)
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Adami, Hans-OlovKarolinska Institutet
(author)
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White, Emily
(author)
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Margolis, Karen L
(author)
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Thun, Michael J
(author)
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Gapstur, Susan M
(author)
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Karolinska InstitutetOrtopedi
(creator_code:org_t)
Related titles
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In:International Journal of Epidemiology: Oxford University Press (OUP)46:3, s. 881-8930300-57711464-3685
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Gaudet, Mia M
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Carter, Brian D
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Brinton, Louise ...
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Falk, Roni T
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Gram, Inger T
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Luo, Juhua
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Milne, Roger L
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Nyante, Sarah J
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Weiderpass, Elis ...
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Beane Freeman, L ...
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Sandler, Dale P
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Robien, Kim
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Anderson, Kristi ...
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Giles, Graham G
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Chen, Wendy Y
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Feskanich, Diane
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Braaten, Tonje
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Isaacs, Claudine
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Butler, Lesley M
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Koh, Woon-Puay
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Wolk, Alicja
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Adami, Hans-Olov
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White, Emily
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Margolis, Karen ...
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Thun, Michael J
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Gapstur, Susan M
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Uppsala University
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Karolinska Institutet