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- Donat-Vargas, CarolinaKarolinska Institutet (författare)
Dietary polychlorinated biphenyls, long-chain n-3 polyunsaturated fatty acids and incidence of malignant melanoma.
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
- Elsevier BV,2017
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-337249
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-337249URI
- https://doi.org/10.1016/j.ejca.2016.11.016DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:135202627URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- BACKGROUND: For malignant melanoma, other risk factors aside from sun exposure have been hardly explored. Polychlorinated biphenyls (PCBs)-mainly from fatty fish- may affect melanogenesis and promote melanoma progression, while long-chain n-3 polyunsaturated fatty acids seem to exert antineoplastic actions in melanoma cells.OBJECTIVES: We aimed to assess the association of validated estimates of dietary PCB exposure as well as the intake of eicosapentaenoic acid and docosahexaenoic acid (EPA-DHA), accounting for sun habits and skin type, with the risk of malignant melanoma in middle-aged and elderly women.METHODS: We included 20,785 women at baseline in 2009 from the prospective population-based Swedish Mammography Cohort. Validated estimates of dietary PCB exposure and EPA-DHA intake were obtained via a food frequency questionnaire. Incident melanoma cases were ascertained through register-linkage.RESULTS: During 4.5 years of follow-up, we ascertained 67 incident cases of melanoma. After multivariable adjustments, exposure to dietary PCBs was associated with four-fold increased risk of malignant melanoma (hazard ratio [HR], 4.0 [95% confidence interval {CI}, 1.2-13; P for trend = 0.02]), while EPA-DHA intake was associated with 80% lower risk (HR, 0.2 [95% CI, 0.1-0.8; P for trend = 0.03]), comparing the highest exposure tertiles with the lowest.CONCLUSION: While we found a direct association between dietary PCB exposure and risk of melanoma, EPA-DHA intake showed to have a substantial protective association. Question of benefits and risk from fish consumption is very relevant and further prospective studies in the general population verifying these findings are warranted.
Ämnesord och genrebeteckningar
- Cancer prevention
- Cutaneous malignant melanoma
- Long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs)
- Nutritional epidemiology
- Polychlorinated biphenyls (PCBs)
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Berglund, MarikaKarolinska Institutet (författare)
- Glynn, Anders (författare)
- Wolk, AlicjaKarolinska Institutet,Uppsala universitet,Ortopedi(Swepub:uu)alwol516 (författare)
- Åkesson, AgnetaKarolinska Institutet (författare)
- Karolinska InstitutetOrtopedi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:European Journal of Cancer: Elsevier BV72, s. 137-1430959-80491879-0852
Internetlänk
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- European Journal of Cancer (Sök värdpublikationen i LIBRIS)
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- Wolk, Alicja
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