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Alcohol consumption...
Alcohol consumption and gastric cancer risk-A pooled analysis within the StoP project consortium.
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Rota, Matteo (author)
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Pelucchi, Claudio (author)
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Bertuccio, Paola (author)
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Matsuo, Keitaro (author)
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Zhang, Zuo-Feng (author)
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Ito, Hidemi (author)
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Hu, Jinfu (author)
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Johnson, Kenneth C (author)
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Palli, Domenico (author)
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Ferraroni, Monica (author)
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Yu, Guo-Pei (author)
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Muscat, Joshua (author)
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Lunet, Nuno (author)
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Peleteiro, Bárbara (author)
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- Ye, Weimin (author)
- Karolinska Institutet
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- Song, Huan (author)
- Karolinska Institutet
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Zaridze, David (author)
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Maximovitch, Dmitry (author)
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Guevara, Marcela (author)
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Fernández-Villa, Tania (author)
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Vioque, Jesus (author)
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Navarrete-Muñoz, Eva M (author)
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- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Ortopedi
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- Orsini, Nicola (author)
- Karolinska Institutet
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Bellavia, Andrea (author)
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- Håkansson, Niclas (author)
- Karolinska Institutet
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Mu, Lina (author)
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Persiani, Roberto (author)
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Kurtz, Robert C (author)
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Lagiou, Areti (author)
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Lagiou, Pagona (author)
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Galeone, Carlotta (author)
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Bonzi, Rossella (author)
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Boffetta, Paolo (author)
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Boccia, Stefania (author)
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Negri, Eva (author)
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La Vecchia, Carlo (author)
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(creator_code:org_t)
- 2017-08-08
- 2017
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 141:10, s. 1950-1962
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https://urn.kb.se/re...
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Abstract
Subject headings
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- An association between heavy alcohol drinking and gastric cancer risk has been recently reported, but the issue is still open to discussion and quantification. We investigated the role of alcohol drinking on gastric cancer risk in the "Stomach cancer Pooling (StoP) Project," a consortium of epidemiological studies. A total of 9,669 cases and 25,336 controls from 20 studies from Europe, Asia and North America were included. We estimated summary odds-ratios (ORs) and the corresponding 95% confidence intervals (CIs) by pooling study-specific ORs using random-effects meta-regression models. Compared with abstainers, drinkers of up to 4 drinks/day of alcohol had no increase in gastric cancer risk, while the ORs were 1.26 (95% CI, 1.08-1.48) for heavy (>4 to 6 drinks/day) and 1.48 (95% CI 1.29-1.70) for very heavy (>6 drinks/day) drinkers. The risk for drinkers of >4 drinks/day was higher in never smokers (OR 1.87, 95% CI 1.35-2.58) as compared with current smokers (OR 1.14, 95% CI 0.93-1.40). Somewhat stronger associations emerged with heavy drinking in cardia (OR 1.61, 95% CI 1.11-2.34) than in non-cardia (OR 1.28, 95% CI 1.13-1.45) gastric cancers, and in intestinal-type (OR 1.54, 95% CI 1.20-1.97) than in diffuse-type (OR 1.29, 95% CI 1.05-1.58) cancers. The association was similar in strata of H. pylori infected (OR = 1.52, 95% CI 1.16-2.00) and noninfected subjects (OR = 1.69, 95% CI 0.95-3.01). Our collaborative pooled-analysis provides definite, more precise quantitative evidence than previously available of an association between heavy alcohol drinking and gastric cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
Keyword
- alcohol drinking
- case-control studies
- gastric cancer
- pooled analysis
- risk factors
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Rota, Matteo
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Pelucchi, Claudi ...
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Bertuccio, Paola
-
Matsuo, Keitaro
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Zhang, Zuo-Feng
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Ito, Hidemi
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show more...
-
Hu, Jinfu
-
Johnson, Kenneth ...
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Palli, Domenico
-
Ferraroni, Monic ...
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Yu, Guo-Pei
-
Muscat, Joshua
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Lunet, Nuno
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Peleteiro, Bárba ...
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Ye, Weimin
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Song, Huan
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Zaridze, David
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Maximovitch, Dmi ...
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Guevara, Marcela
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Fernández-Villa, ...
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Vioque, Jesus
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Navarrete-Muñoz, ...
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Wolk, Alicja
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Orsini, Nicola
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Bellavia, Andrea
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Håkansson, Nicla ...
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Mu, Lina
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Persiani, Robert ...
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Kurtz, Robert C
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Lagiou, Areti
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Lagiou, Pagona
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Galeone, Carlott ...
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Bonzi, Rossella
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Boffetta, Paolo
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Boccia, Stefania
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Negri, Eva
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La Vecchia, Carl ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Gastroenterology ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Substance Abuse
- Articles in the publication
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International Jo ...
- By the university
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Uppsala University
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Karolinska Institutet