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Transplantation of ...
Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
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- Carlsson, Per-Ola (author)
- Uppsala universitet,Transplantation och regenerativ medicin,Institutionen för medicinsk cellbiologi
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- Espes, Daniel, 1985- (author)
- Uppsala universitet,Transplantation och regenerativ medicin,Institutionen för medicinsk cellbiologi
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- Sedigh, Amir (author)
- Uppsala universitet,Transplantationskirurgi
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Rotem, Avi (author)
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Zimermann, Baruch (author)
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Grinberg, Helena (author)
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Goldman, Tali (author)
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Barkai, Uriel (author)
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Avni, Yuval (author)
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- Westermark, Gunilla T. (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Carlbom, Lina (author)
- Uppsala universitet,Radiologi
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- Ahlström, Håkan, 1953- (author)
- Uppsala universitet,Radiologi,Antaros Medical AB, Mölndal, Sweden
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- Eriksson, Olof (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Olerud, Johan (author)
- Uppsala universitet,Klinisk immunologi
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- Korsgren, Olle (author)
- Uppsala universitet,Klinisk immunologi
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: American Journal of Transplantation. - : Elsevier BV. - 1600-6135 .- 1600-6143. ; 18:7, s. 1735-1744
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Abstract
Subject headings
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- Macroencapsulation devices provide the dual possibility to immunoprotect transplanted cells while also being retrievable; the latter bearing importance for safety in future trials with stem-cell derived cells. However, macroencapsulation entails a problem with oxygen supply to the encapsulated cells. The βAir device solves this with an incorporated refillable oxygen tank. This phase 1 study evaluated the safety and efficacy of implanting the βAir device containing allogeneic human pancreatic islets to patients with type 1 diabetes. Four patients were transplanted with 1-2 βAir devices, each containing 155000-180000 IEQ (i.e. 1800-4600 IEQ per kg body weight), and monitored for 3-6 months, followed by the recovery of devices. Implantation of the βAir device was safe and successfully prevented immunization and rejection of the transplanted tissue. However, although beta cells survived in the device, only minute levels of circulating C-peptide were observed with no impact on metabolic control. Fibrotic tissue with immune cells was formed in capsule surroundings. Recovered devices displayed a blunted glucose-stimulated insulin response, and amyloid formation in the endocrine tissue. We conclude that the βAir device is safe and can support survival of allogeneic islets for several months, although the function of the transplanted cells was limited.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- cellular biology
- clinical research
- practice
- diabetes: type 1
- encapsulation
- endocrinology
- diabetology
- islet transplantation
- islets of Langerhans
- translational research
- science
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Carlsson, Per-Ol ...
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Espes, Daniel, 1 ...
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Sedigh, Amir
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Rotem, Avi
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Zimermann, Baruc ...
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Grinberg, Helena
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show more...
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Goldman, Tali
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Barkai, Uriel
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Avni, Yuval
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Westermark, Guni ...
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Carlbom, Lina
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Ahlström, Håkan, ...
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Eriksson, Olof
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Olerud, Johan
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Korsgren, Olle
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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American Journal ...
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Uppsala University