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Genomic signatures ...
Genomic signatures of 60 years of bidirectional selection for 8-week body weight in chickens
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- Lillie, Mette (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Örjan Carlborg
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- Sheng, Zheya (author)
- Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, People’s Republic of China,Örjan Carlborg
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- Honaker, Christa (author)
- Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden; Department of Veterinary Integrative Biosciences, Texas A&M University, College Station,Leif Andersson,Institutionen för husdjursgenetik (HGEN),Uppsala University,Texas A&M University
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- Siegel, Paul (author)
- Department of Animal and Poultry Sciences, Virginia Polytechnic Institute and State University, Blacksburg
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- Carlborg, Örjan (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Örjan Carlborg
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(creator_code:org_t)
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- Elsevier BV, 2018
- 2018
- English.
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In: Poultry Science. - : Elsevier BV. - 0032-5791 .- 1525-3171. ; 97:3, s. 781-790
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Abstract
Subject headings
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- Sixty years, constituting 60 generations, have passed since the founding of the Virginia body weight lines, an experimental population of White Plymouth Rock chickens. Using a stringent breeding scheme for divergent 8-week body weight, the lines, which originated from a common founder population, have responded to bidirectional selection with an approximate 15-fold difference in the selected trait. They provide a model system to study the genetics of complex traits in general and the influences of artificial selection on quantitative genetic architectures in particular. As we reflect on the 60th anniversary of the initiation of the Virginia body weight lines, there is opportunity to discuss the findings obtained using different analytical and experimental genetic and genomic strategies and integrate them with a recent pooled genome resequencing dataset. Hundreds of regions across the genome show differentiation between the 2 lines, reinforcing previous findings that response to selection relied on standing variation across many genes and giving insights into the haplotype complexity underlying regions associated with body weight.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Jordbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Agricultural Science (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Keyword
- body weight
- quantitative trait
- polygenic selection
- chicken
- haplotype complexity
- Genetik
- Genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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