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Extramedullary leuk...
Extramedullary leukemia in children with acute myeloid leukemia : A population-based cohort study from the Nordic Society of Pediatric Hematology and Oncology (NOPHO)
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- Stove, Heidi Kristine (author)
- Aarhus Univ Hosp, Dept Pediat, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Sandahl, Julie Damgaard (author)
- Aarhus Univ Hosp, Dept Pediat, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Abrahamsson, Jonas (author)
- Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden.
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- Asdahl, Peter H. (author)
- Aarhus Univ Hosp, Dept Pediat, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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- Forestier, Erik (author)
- Umea Univ Hosp, Dept Med Biosci & Genet, Umea, Sweden.
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- Ha, Shau-Yin (author)
- Queen Mary Hosp, Hong Kong Pediat Hematol & Oncol Study Grp, Dept Pediat, Hong Kong, Hong Kong, Peoples R China.
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- Jahnukainen, Kirsi (author)
- Univ Helsinki, Childrens Hosp, Helsinki, Finland.;Helsinki Univ Hosp, Helsinki, Finland.
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- Jonsson, Olafur G. (author)
- Landspitalinn, Dept Pediat, Reykjavik, Iceland.
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- Lausen, Birgitte (author)
- Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.
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- Palle, Josefine, 1964- (author)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Zeller, Bernward (author)
- Oslo Univ Hosp, Dept Pediat Med, Oslo, Norway.
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- Hasle, Henrik (author)
- Aarhus Univ Hosp, Dept Pediat, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark.
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Aarhus Univ Hosp, Dept Pediat, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark Queen Silvia Childrens Hosp, Inst Clin Sci, Dept Pediat, Gothenburg, Sweden. (creator_code:org_t)
- 2017-03-23
- 2017
- English.
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In: Pediatric Blood & Cancer. - : Wiley. - 1545-5009 .- 1545-5017. ; 64:12
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: The prognostic significance of extramedullary leukemia (EML) in childhood acute myeloid leukemia is not clarified. Procedure: This population-based study included 315 children from the NOPHO-AML 2004 trial. Results: At diagnosis, 73 (23%) patients had EML: 39 (12%) had myeloid sarcoma, 22 (7%) had central nervous system disease, and 12 (4%) had both. EML was associated with young age (median age: 2.6 years), a high white blood cell count (median: 40 x 10(9)/l), M5 morphology (40%), and 11q23/MLL (KMT2A) rearrangements (34%). No patient received involved field radiotherapy. Five-year event-free survival did not differ significantly between the EML and the non-EML patients (54% vs. 45%, P = 0.57), whereas 5-year overall survival (OS) was significantly lower in the EML group (64% vs. 73%, P = 0.04). The risk of induction death was significantly higher for EML patients (8% vs. 1%, P = 0.002). There was a trend toward a lower risk of relapse for EML patients (5-year cumulative incidence of relapse 33% vs. 49%, P = 0.16). Traumatic lumbar puncture did not adversely affect survival in this cohort. Conclusions: EML was associated with increased risk of induction death impacting the OS. No patients relapsed at the primary site of the myeloid sarcoma despite management without radiotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- acute myeloid leukemia
- central nervous system disease
- children
- chloroma
- extramedullary leukemia
Publication and Content Type
- ref (subject category)
- art (subject category)
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Stove, Heidi Kri ...
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Sandahl, Julie D ...
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Abrahamsson, Jon ...
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Asdahl, Peter H.
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Forestier, Erik
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Ha, Shau-Yin
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Jahnukainen, Kir ...
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Jonsson, Olafur ...
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Lausen, Birgitte
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Palle, Josefine, ...
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Zeller, Bernward
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Hasle, Henrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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Pediatric Blood ...
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Uppsala University