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Systemic AA amyloid...
Systemic AA amyloidosis in the red fox (Vulpes vulpes)
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- Rising, Anna (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Karolinska Institutet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Karolinska Institute
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- Cederlund, Ella (author)
- Karolinska Inst, Dept Med Biochem & Biophys MBB, S-17177 Stockholm, Sweden.
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- Palmberg, Carina (author)
- Karolinska Institutet
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- Uhlhorn, Henrik (author)
- Natl Vet Inst SVA, Dept Pathol & Wildlife Dis, S-75189 Uppsala, Sweden.
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- Gaunitz, Stefan (author)
- Karolinska Institutet
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- Nordling, Kerstin (author)
- Karolinska Institutet
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- Agren, Erik (author)
- Natl Vet Inst SVA, Dept Pathol & Wildlife Dis, S-75189 Uppsala, Sweden.
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- Ihse, Elisabet (author)
- Uppsala universitet,Klinisk och experimentell patologi,Per Westermark
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- Westermark, Gunilla (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Tjernberg, Lars (author)
- Karolinska Institutet
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- Jornvall, Hans (author)
- Karolinska Inst, Dept Med Biochem & Biophys MBB, S-17177 Stockholm, Sweden.
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- Johansson, Jan (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Karolinska Institutet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Karolinska Institute
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- Westermark, Per (author)
- Uppsala universitet,Klinisk och experimentell patologi,Per Westermark
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(creator_code:org_t)
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- 2017-09-13
- 2017
- English.
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In: Protein Science. - : WILEY. - 0961-8368 .- 1469-896X. ; 26:11, s. 2312-2318
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Abstract
Subject headings
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- Amyloid A (AA) amyloidosis occurs spontaneously in many mammals and birds, but the prevalence varies considerably among different species, and even among subgroups of the same species. The Blue fox and the Gray fox seem to be resistant to the development of AA amyloidosis, while Island foxes have a high prevalence of the disease. Herein, we report on the identification of AA amyloidosis in the Red fox (Vulpes vulpes). Edman degradation and tandem MS analysis of proteolyzed amyloid protein revealed that the amyloid partly was composed of full-length SAA. Its amino acid sequence was determined and found to consist of 111 amino acid residues. Based on inter-species sequence comparisons we found four residue exchanges (Ser31, Lys63, Leu71, Lys72) between the Red and Blue fox SAAs. Lys63 seems unique to the Red fox SAA. We found no obvious explanation to how these exchanges might correlate with the reported differences in SAA amyloidogenicity. Furthermore, in contrast to fibrils from many other mammalian species, the isolated amyloid fibrils from Red fox did not seed AA amyloidosis in a mouse model.
Subject headings
- LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- amyloid
- protein aggregation
- disease
- seeding
- serum amyloid A
- Patologi
- Pathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Rising, Anna
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Cederlund, Ella
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Palmberg, Carina
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Uhlhorn, Henrik
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Gaunitz, Stefan
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Nordling, Kersti ...
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show more...
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Agren, Erik
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Ihse, Elisabet
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Westermark, Guni ...
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Tjernberg, Lars
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Jornvall, Hans
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Johansson, Jan
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Westermark, Per
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Veterinary Scien ...
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and Medical Bioscien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Protein Science
- By the university
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Uppsala University
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Karolinska Institutet
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Swedish University of Agricultural Sciences