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  • Bulanova, DariaUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-09-25
  • MDPI AG,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-341625
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341625URI
  • https://doi.org/10.3390/v9100271DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensitizes cells containing foreign RNA or DNA to apoptosis. A comparison of the toxicity, antiviral activity, and side effects of six Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate. Thus, our results pave the way for the further development of Bcl-2i for the prevention and treatment of viral diseases.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ianevski, AleksandrUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Bugai, AndriiUniv Helsinki, Dept Biochem & Dev Biol, FIN-00290 Helsinki, Finland. (author)
  • Akimov, YevhenUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Kuivanen, SuviUniv Helsinki, Dept Virol, Haartmaninkatu 3, FIN-00290 Helsinki, Finland. (author)
  • Paavilainen, HenrikUniv Turku, Dept Virol, FIN-20520 Turku, Finland. (author)
  • Kakkola, LauraUniv Turku, Dept Virol, FIN-20520 Turku, Finland. (author)
  • Nandania, JatinUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Turunen, LauraUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Ohman, TiinaUniv Helsinki, Inst Biotechnol, Valimotie 7, Helsinki 00014, Finland. (author)
  • Ala-Hongisto, HannaBiomed Funct Genom Unit FuGU, Helsinki 00290, Helsinki, Finland. (author)
  • Pesonen, Hanna M.Biomed Funct Genom Unit FuGU, Helsinki 00290, Helsinki, Finland. (author)
  • Kuisma, Marika S.Biomed Funct Genom Unit FuGU, Helsinki 00290, Helsinki, Finland. (author)
  • Honkimaa, AnniUniv Tampere, Dept Virol, Tampere 33520, Finland. (author)
  • Walton, Emma L.Norwegian Univ Sci & Technol, Dept Clin & Mol Med, N-7028 Trondheim, Norway. (author)
  • Oksenych, ValentynNorwegian Univ Sci & Technol, Dept Clin & Mol Med, N-7028 Trondheim, Norway. (author)
  • Lorey, Martina B.Univ Helsinki, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Rheumatol, Helsinki 00290, Finland. (author)
  • Guschin, DmitryInst Pasteur Korea, Gyeonggi Do 13488, South Korea. (author)
  • Shim, JungminInst Pasteur Korea, Gyeonggi Do 13488, South Korea. (author)
  • Kim, JinheeInst Pasteur Korea, Gyeonggi Do 13488, South Korea. (author)
  • Than, Thoa T.Inst Pasteur Korea, Gyeonggi Do 13488, South Korea. (author)
  • Chang, So YoungInst Pasteur Korea, Gyeonggi Do 13488, South Korea. (author)
  • Hukkanen, VeijoUniv Turku, Dept Virol, FIN-20520 Turku, Finland. (author)
  • Kulesskiy, EvgenyUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Marjomaki, Varpu S.Univ Jyvaskyla, Dept Biol & Environm Sci, Nanosci Ctr, Jyvaskyla 40500, Finland. (author)
  • Julkunen, IlkkaUniv Turku, Dept Virol, FIN-20520 Turku, Finland. (author)
  • Nyman, Tuula A.Univ Helsinki, Inst Biotechnol, Valimotie 7, Helsinki 00014, Finland.;Univ Oslo, Dept Immunol, N-0424 Oslo, Norway. (author)
  • Matikainen, SampsaUniv Helsinki, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Rheumatol, Helsinki 00290, Finland. (author)
  • Saarela, Jani S.Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Sane, FamaraUniv Lille, CHU Lille, Lab Virol, EA3610, F-59037 Lille, France. (author)
  • Hober, DidierUniv Lille, CHU Lille, Lab Virol, EA3610, F-59037 Lille, France. (author)
  • Gabriel, GuelsahLeibniz Inst Expt Virol, Heinrich Pette Inst, D-20251 Hamburg, Germany. (author)
  • De Brabander, Jef K.Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA. (author)
  • Martikainen, MiikaUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk immunologi(Swepub:uu)miima874 (author)
  • Windisch, Marc P.Inst Pasteur Korea, Gyeonggi Do 13488, South Korea. (author)
  • Min, Ji-YoungInst Pasteur Korea, Gyeonggi Do 13488, South Korea. (author)
  • Bruzzone, RobertoInst Pasteur Korea, Gyeonggi Do 13488, South Korea.;Univ Hong Kong, Sch Publ Hlth, HKU Pasteur Res Pole, Hong Kong, Hong Kong, Peoples R China.;Inst Pasteur, Dept Cell Biol & Infect, F-75015 Paris, France. (author)
  • Aittokallio, TeroUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Vaha-Koskela, MarkusUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Vapalahti, OlliUniv Helsinki, Dept Virol & Immunol, FIN-00014 Helsinki, Finland.;Helsinki Univ Hosp, Helsinki 00014, Finland.;Univ Helsinki, Dept Vet Biosci, FIN-00014 Helsinki, Finland. (author)
  • Pulk, ArtoUniv Tartu, Inst Technol, EE-50090 Tartu, Estonia. (author)
  • Velagapudi, VidyaUniv Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland. (author)
  • Kainov, Denis E.Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, N-7028 Trondheim, Norway.;Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.;Univ Tartu, Inst Technol, EE-50090 Tartu, Estonia. (author)
  • Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.Univ Helsinki, Dept Biochem & Dev Biol, FIN-00290 Helsinki, Finland. (creator_code:org_t)

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