Search: onr:"swepub:oai:DiVA.org:uu-341785" >
Optimal timing of t...
Optimal timing of tau pathology imaging and automatic extraction of a reference region using dynamic [18F]THK5317 PET
-
- Jonasson, My (author)
- Uppsala universitet,Radiologi,Nuclear Medicine and PET
-
- Wall, Anders (author)
- Uppsala universitet,Radiologi,Institutionen för läkemedelskemi,Nuclear Medicine and PET
-
- Chiotis, Konstantinos (author)
- Karolinska Institutet
-
show more...
-
- Leuzy, Antoine (author)
- Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
-
- Eriksson, Jonas (author)
- Uppsala universitet,Preparativ läkemedelskemi
-
- Antoni, Gunnar (author)
- Uppsala universitet,Preparativ läkemedelskemi
-
- Nordberg, Agneta (author)
- Karolinska Institutet
-
- Lubberink, Mark (author)
- Uppsala universitet,Radiologi,Nuclear Medicine and PET
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2019
- 2019
- English.
-
In: NeuroImage. - : Elsevier BV. - 2213-1582. ; 22
- Related links:
-
https://uu.diva-port... (primary) (Raw object)
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- [F-18]THK5317 is a PET tracer for in-vivo imaging of tau associated with Alzheimer's disease (AD). This work aimed to evaluate optimal timing for standardized uptake value ratio (SUVR) measures with [F-18]THK5317 and automated generation of SUVR-1 and relative cerebral blood flow (R-1) parametric images. Nine AD patients and nine controls underwent 90 min [F-18]THK5317 scans. SUVR-1 was calculated at transient equilibrium (TE) and for seven different 20 min intervals and compared with distribution volume ratio (DVR; reference Logan). Cerebellar grey matter (MRI) was used as reference region. A supervised cluster analysis (SVCA) method was implemented to automatically generate a reference region, directly from the dynamic PET volume without the need of a structural MRI scan, for computation of SUVR-1 and R-1 images for a scan duration matching the optimal timing. TE was reached first in putamen, frontal- and parietal cortex at 22 +/- 4 min for AD patients and in putamen at 20 +/- 0 min in controls. Over all regions and subjects, SUVR20-40-1 correlated best with DVR-1, R-2 = 0.97. High correlation was found between values generated using MRI- and SVCA-based reference (R-2 = 0.93 for SUVR20-40-1; R-2 = 0.94 for R-1). SUVR20-40 allows for accurate semi-quantitative assessment of tau pathology and SVCA may be used to obtain a reference region for calculation of both SUVR-1 and R-1 with 40 min scan duration.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Alzheimer’s disease
- PET
- Parametric images
- Supervised clustering
- Tau imaging
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
NeuroImage
(Search for host publication in LIBRIS)
To the university's database