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Elevated heparanase expression is associated with poor prognosis in breast cancer : a study based on systematic review and TCGA data
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- Sun, Xu (author)
- Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.
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- Zhang, Ganlin (author)
- Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.
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- Nian, Jiayun (author)
- Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.;Beijing Univ Chinese Med, Sch Grad, Beijing, Peoples R China.
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- Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China Capital Med Univ, Dept Oncol, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.;Beijing Univ Chinese Med, Sch Grad, Beijing, Peoples R China. (creator_code:org_t)
- 2017-03-25
- 2017
- English.
- In: Oncotarget. - : IMPACT JOURNALS LLC. - 1949-2553. ; 8:26, s. 43521-43535
- Research review (peer-reviewed)
Abstract
Subject headings
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- Heparanase promotes tumorigenesis, angiogenesis, and metastasis. Here, we conducted a study based on systematic review and the Cancer Genome Atlas (TCGA) data that examined heparanase expression in clinical samples to determine its prognostic value. According to the meta-analysis and TCGA data, we found that heparanase expression was up-regulated in most breast cancer specimens, and elevated heparanase expression was associated with increased lymph node metastasis, larger tumor size, higher histological grade, and poor survival. These results suggest that targeting heparanase might improve treatments for breast cancer patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- heparanase
- breast cancer
- prognosis
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- By the author/editor
- Sun, Xu
- Zhang, Ganlin
- Nian, Jiayun
- Yu, Mingwei
- Chen, Shijian
- Zhang, Yi
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- Yang, Guowang
- Yang, Lin
- Cheng, Peiyu
- Yan, Chen
- Ma, Yunfei
- Meng, Hui
- Wang, Xiaomin
- Li, Jin-Ping
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Oncotarget
- By the university
- Uppsala University
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