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Interleukin-33 Prom...
Interleukin-33 Promotes Recruitment of Microglia/Macrophages in Response to Traumatic Brain Injury
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- Wicher, Grzegorz K. (author)
- Uppsala universitet,Neuroonkologi,Science for Life Laboratory, SciLifeLab
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- Wallenquist, Ulrika (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Lei, Ying (author)
- Karolinska Inst, Immunol & Allergy Unit, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
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- Enoksson, Mattias (author)
- Karolinska Inst, Immunol & Allergy Unit, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
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- Li, Xiaofei (author)
- Karolinska Institutet,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
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- Fuchs, Barbara (author)
- Karolinska Inst, Immunol & Allergy Unit, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
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- Abu Hamdeh, Sami (author)
- Uppsala universitet,Neurokirurgi
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- Marklund, Niklas (author)
- Uppsala universitet,Neurokirurgi
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- Hillered, Lars, 1952- (author)
- Uppsala universitet,Neurokirurgi
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- Nilsson, Gunnar (author)
- Karolinska Institutet,Uppsala universitet,Hematologi,Karolinska Inst, Immunol & Allergy Unit, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden.
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- Forsberg Nilsson, Karin, 1963- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Neuroonkologi
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(creator_code:org_t)
- Mary Ann Liebert Inc, 2017
- 2017
- English.
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In: Journal of Neurotrauma. - : Mary Ann Liebert Inc. - 0897-7151 .- 1557-9042. ; 34:22, s. 3173-3182
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Traumatic brain injury (TBI) is a devastating condition, often leading to life-long consequences for patients. Even though modern neurointensive care has improved functional and cognitive outcomes, efficient pharmacological therapies are still lacking. Targeting peripherally derived, or resident inflammatory, cells that are rapid responders to brain injury is promising, but complex, given that the contribution of inflammation to exacerbation versus improved recovery varies with time post-injury. The injury-induced inflammatory response is triggered by release of alarmins, and in the present study we asked whether interleukin-33 (IL-33), an injury-associated nuclear alarmin, is involved in TBI. Here, we used samples from human TBI microdialysate, tissue sections from human TBI, and mouse models of central nervous system injury and found that expression of IL-33 in the brain was elevated from nondetectable levels, reaching a maximum after 72 h in both human samples and mouse models. Astrocytes and oligodendrocytes were the main producers of IL-33. Post-TBI, brains of mice deficient in the IL-33 receptor, ST2, contained fewer microglia/macrophages in the injured region than wild-type mice and had an altered cytokine/chemokine profile in response to injury. These observations indicate that IL-33 plays a role in neuroinflammation with microglia/macrophages being cellular targets for this interleukin post-TBI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- alarmin
- glia
- microglia
- traumatic brain injury
- neuroinflammation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Wicher, Grzegorz ...
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Wallenquist, Ulr ...
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Lei, Ying
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Enoksson, Mattia ...
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Li, Xiaofei
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Fuchs, Barbara
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show more...
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Abu Hamdeh, Sami
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Marklund, Niklas
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Hillered, Lars, ...
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Nilsson, Gunnar
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Forsberg Nilsson ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Neuro ...
- By the university
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Uppsala University
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Karolinska Institutet