Search: onr:"swepub:oai:DiVA.org:uu-342920" >
RANK rewires energy...
-
Rao, ShuanAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
2017-11-08
-
Cold Spring Harbor Laboratory,2017
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-342920
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-342920URI
-
https://doi.org/10.1101/gad.304162.117DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:137064484URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Lung cancer is the leading cause of cancer deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung cancer in women; however, the underlying mechanisms remain unclear. Here we report that the receptor activator of nuclear factor-kB (RANK), the key regulator of osteoclastogenesis, is frequently expressed in primary lung tumors, an active RANK pathway correlates with decreased survival, and pharmacologic RANK inhibition reduces tumor growth in patient-derived lung cancer xenografts. Clonal genetic inactivation of KRas(G12D) in mouse lung epithelial cells markedly impairs the progression of KRas(G12D)-driven lung cancer, resulting in a significant survival advantage. Mechanistically, RANK rewires energy homeostasis in human and murine lung cancer cells and promotes expansion of lung cancer stem-like cells, which is blocked by inhibiting mitochondrial respiration. Our data also indicate survival differences in KRas(G12D)-driven lung cancer between male and female mice, and we show that female sex hormones can promote lung cancer progression via the RANK pathway. These data uncover a direct role for RANK in lung cancer and may explain why female sex hormones accelerate lung cancer development. Inhibition of RANK using the approved drug denosumab may be a therapeutic drug candidate for primary lung cancer.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Sigl, VerenaAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Wimmer, Reiner AloisAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Novatchkova, MariaAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Jais, AlexanderMed Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria.;Max Planck Inst Metab Res, Dept Neuronal Control Metab, D-50931 Cologne, Germany.
(author)
-
Wagner, GabrielMed Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria.
(author)
-
Handschuh, StephanUniv Vet Med, VetCore Facil Res, A-1220 Vienna, Austria.
(author)
-
Uribesalgo, IrisAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Hagelkruys, AstridAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Kozieradzki, IvonaAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Tortola, LuigiAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Nitsch, RobertoAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Cronin, Shane J.Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Orthofer, MichaelAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Branstetter, DanielAmgen Inc, Dept Pathol, Seattle, WA 98119 USA.
(author)
-
Canon, JudeAmgen Inc, Dept Oncol Res, Seattle, WA 98119 USA.
(author)
-
Rossi, JohnAmgen Inc, Dept Mol Sci, Seattle, WA 98119 USA.
(author)
-
D'Arcangelo, ManoloUniv Colorado, Ctr Canc, Aurora, CO 80045 USA.
(author)
-
Botling, JohanUppsala universitet,Klinisk och experimentell patologi,Johan Botling(Swepub:uu)johanbot
(author)
-
Micke, PatrickUppsala universitet,Klinisk och experimentell patologi,Patrick Micke(Swepub:uu)patmi676
(author)
-
La Fleur, LinneaUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Johan Botling(Swepub:uu)linla513
(author)
-
Edlund, KarolinaLeibniz Res Ctr Working Environm & Human Factors, D-44139 Dortmund, Germany.
(author)
-
Bergqvist, MichaelGavle Cent Hosp, Dept Oncol, S-80187 Gavle, Sweden.
(author)
-
Ekman, SimonKarolinska Institutet
(author)
-
Lendl, ThomasGregor Mendel Inst Mol Plant Biol GMI, A-1030 Vienna, Austria.
(author)
-
Popper, HelmutMed Univ Graz, Inst Pathol, Res Unit Mol Lung & Pleura Pathol, A-8036 Graz, Austria.
(author)
-
Takayanagi, HiroshiUniv Tokyo, Dept Immunol, Tokyo 1088639, Japan.
(author)
-
Kenner, LukasMed Univ Vienna, Dept Clin Pathol, A-1090 Vienna, Austria.;Ludwig Boltzmann Inst Canc Res, A-1090 Vienna, Austria.;Univ Vet Med Vienna, Unit Pathol Lab Anim, A-1220 Vienna, Austria.
(author)
-
Hirsch, Fred R.Univ Colorado, Ctr Canc, Aurora, CO 80045 USA.
(author)
-
Dougall, WilliamAmgen Inc, Dept Oncol Res, Seattle, WA 98119 USA.;QIMR, Berghofer Med Res Inst, Dept Immunol Canc & Infect, Brisbane, Qld 4006, Australia.
(author)
-
Penninger, JosefAustrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.
(author)
-
Austrian Acad Sci IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria.Med Univ Vienna, Dept Lab Med, A-1090 Vienna, Austria.;Max Planck Inst Metab Res, Dept Neuronal Control Metab, D-50931 Cologne, Germany.
(creator_code:org_t)
Related titles
-
In:Genes & Development: Cold Spring Harbor Laboratory31:20, s. 2099-21120890-93691549-5477
Internet link
Find in a library
To the university's database
- By the author/editor
-
Rao, Shuan
-
Sigl, Verena
-
Wimmer, Reiner A ...
-
Novatchkova, Mar ...
-
Jais, Alexander
-
Wagner, Gabriel
-
show more...
-
Handschuh, Steph ...
-
Uribesalgo, Iris
-
Hagelkruys, Astr ...
-
Kozieradzki, Ivo ...
-
Tortola, Luigi
-
Nitsch, Roberto
-
Cronin, Shane J.
-
Orthofer, Michae ...
-
Branstetter, Dan ...
-
Canon, Jude
-
Rossi, John
-
D'Arcangelo, Man ...
-
Botling, Johan
-
Micke, Patrick
-
La Fleur, Linnea
-
Edlund, Karolina
-
Bergqvist, Micha ...
-
Ekman, Simon
-
Lendl, Thomas
-
Popper, Helmut
-
Takayanagi, Hiro ...
-
Kenner, Lukas
-
Hirsch, Fred R.
-
Dougall, William
-
Penninger, Josef
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Clinical Laborat ...
- Articles in the publication
-
Genes & Developm ...
- By the university
-
Uppsala University
-
Karolinska Institutet