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Islet xenotransplantation : An immunological study in the pig-to-mouse model
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- Benda, Birgitta (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
- (creator_code:org_t)
- ISBN 9155444962
- Uppsala : Acta Universitatis Upsaliensis, 1999
- English 43 s.
- Series: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 0282-7476 ; 852
- Doctoral thesis (other academic/artistic)
Abstract
Subject headings
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- Successful clinical xenotransplantation, i.e., transplantation between species, would eliminate the shortage of donor organs. In order to study the acute cellular rejection reaction following discordant xenogeneic transplantation, an experimental pig-to- mouse islet xenotransplantation model was established. Further, immunological processes were evaluated using genetically deficient (knock-out) recipient mice and pharmacological agents exerting cytokine-modulatory actions.Xenogeneic islet transplantation persists in mice deficient in antibodies, interleukin-6, perforin or granzyme B, suggesting that neither xenoreactive antibodies or interleukin-6 nor granule-mediated lysis are of critical importance to the rejection process. Instead, the immune response following pig-to-mouse islet xenotransplantation bears a close morphological resemblance to a T helper (Th) 1-dependent delayed-type hypersensitivity-reaction with a massive infiltration of macrophages and comparatively small amounts of peripherally accumulated T cells. It may be speculated that islet xenograft destruction is a macrophage-mediated process regulated by T cells. Indeed, Th1-associated cytokines with macrophage-activating properties (interferon-γ and tumor necrosis factor-α) and interleukin-2 seem to be important to islet xenograft rejection, even though other cytokines eventually substitute for the lack of those in a majority of animals.Key words: xenotransplantation, porcine, islet, in vivo, knock-out mouse,immunohistochemistry, CsA, MDL 201,449A, Ig, FcR, IL-6, perforin, granzyme B,macrophage, eosinophilic granulocyte, T cell, TCR, IFN- g, TNF- a, IL-2.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Oncology
- xenotransplantation
- porcine
- islet
- in vivo
- knock-out mouse
- immunohistochemistry
- CsA
- MDL 201
- 449A
- Ig
- FcR
- IL-6
- perforin
- granzyme B
- macrophage
- eosinophilic granulocyte
- T cell
- TCR
- IFN- g
- TNF- a
- IL-2
- Onkologi
- Oncology
- Onkologi
- Clinical Immunology
- klinisk immunologi
Publication and Content Type
- vet (subject category)
- dok (subject category)
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