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Advances in the Cla...
Advances in the Classification and Treatment of Mastocytosis : Current Status and Outlook toward the Future.
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Valent, Peter (author)
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Akin, Cem (author)
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Hartmann, Karin (author)
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- Nilsson, Gunnar (author)
- Karolinska Institutet
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Reiter, Andreas (author)
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Hermine, Olivier (author)
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Sotlar, Karl (author)
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Sperr, Wolfgang R (author)
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Escribano, Luis (author)
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George, Tracy I (author)
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Kluin-Nelemans, Hanneke C (author)
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Ustun, Celalettin (author)
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Triggiani, Massimo (author)
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Brockow, Knut (author)
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Gotlib, Jason (author)
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Orfao, Alberto (author)
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Schwartz, Lawrence B (author)
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Broesby-Olsen, Sigurd (author)
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Bindslev-Jensen, Carsten (author)
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Kovanen, Petri T (author)
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Galli, Stephen J (author)
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Austen, K Frank (author)
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Arber, Daniel A (author)
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Horny, Hans-Peter (author)
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Arock, Michel (author)
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Metcalfe, Dean D (author)
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(creator_code:org_t)
- 2017
- 2017
- English.
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In: Cancer Research. - 0008-5472 .- 1538-7445. ; 77:6, s. 1261-1270
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Mastocytosis is a term used to denote a heterogeneous group of conditions defined by the expansion and accumulation of clonal (neoplastic) tissue mast cells in various organs. The classification of the World Health Organization (WHO) divides the disease into cutaneous mastocytosis, systemic mastocytosis, and localized mast cell tumors. On the basis of histomorphologic criteria, clinical parameters, and organ involvement, systemic mastocytosis is further divided into indolent systemic mastocytosis and advanced systemic mastocytosis variants, including aggressive systemic mastocytosis and mast cell leukemia. The clinical impact and prognostic value of this classification has been confirmed in numerous studies, and its basic concept remains valid. However, refinements have recently been proposed by the consensus group, the WHO, and the European Competence Network on Mastocytosis. In addition, new treatment options are available for patients with advanced systemic mastocytosis, including allogeneic hematopoietic stem cell transplantation and multikinase inhibitors directed against KIT D816V and other key signaling molecules. Our current article provides an overview of recent advances in the field of mastocytosis, with emphasis on classification, prognostication, and emerging new treatment options in advanced systemic mastocytosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Valent, Peter
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Akin, Cem
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Hartmann, Karin
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Nilsson, Gunnar
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Reiter, Andreas
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Hermine, Olivier
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show more...
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Sotlar, Karl
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Sperr, Wolfgang ...
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Escribano, Luis
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George, Tracy I
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Kluin-Nelemans, ...
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Ustun, Celaletti ...
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Triggiani, Massi ...
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Brockow, Knut
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Gotlib, Jason
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Orfao, Alberto
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Schwartz, Lawren ...
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Broesby-Olsen, S ...
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Bindslev-Jensen, ...
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Kovanen, Petri T
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Galli, Stephen J
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Austen, K Frank
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Arber, Daniel A
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Horny, Hans-Pete ...
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Arock, Michel
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Metcalfe, Dean D
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Cancer Research
- By the university
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Uppsala University
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Karolinska Institutet