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Mast Cell Infiltrat...
Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential
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- Roy, Ananya (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Neuroonkologi,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,Uppsala University
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- Libard, Sylwia (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Weishaupt, Holger (author)
- Uppsala universitet,Neuroonkologi
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- Gustavsson, Ida (author)
- Uppsala universitet,Neuroonkologi
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- Uhrbom, Lene (author)
- Uppsala universitet,Neuroonkologi
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- Hesselager, Göran (author)
- Uppsala universitet,Neurokirurgi
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- Johansson, Fredrik K., 1975- (author)
- Uppsala universitet,Neuroonkologi
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- Ponten, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Alafuzoff, Irina (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- Tchougounova, Elena (author)
- Uppsala universitet,Neuroonkologi,Uppsala University
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(creator_code:org_t)
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- 2017-06-02
- 2017
- English.
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In: Frontiers in Oncology. - : Frontiers Media SA. - 2234-943X. ; 7
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Abstract
Subject headings
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- Metastatic brain tumors continue to be a clinical problem, despite new therapeutic advances in cancer treatment. Brain metastases (BMs) are among the most common mass lesions in the brain that are resistant to chemotherapies, have a very poor prognosis, and currently lack any efficient diagnostic tests. Predictions estimate that about 40% of lung and breast cancer patients will develop BM. Despite this, very little is known about the immunological and genetic aberrations that drive tumorigenesis in BM. In this study, we demonstrate the infiltration of mast cells (MCs) in a large cohort of human BM samples with different tissues of origin for primary cancer. We applied patient-derived BM cell models to the study of BM cell-MC interactions. BM cells when cocultured with MCs demonstrate enhanced growth and self-renewal capacity. Gene set enrichment analyses indicate increased expression of signal transduction and transmembrane proteins related genes in the cocultured BM cells. MCs exert their effect by release of mediators such as IL-8, IL-10, matrix metalloprotease 2, and vascular endothelial growth factor, thereby permitting metastasis. In conclusion, we provide evidence for a role of MCs in BM. Our findings indicate MCs' capability of modulating gene expression in BM cells and suggest that MCs can serve as a new target for drug development against metastases in the brain.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- IL-10
- IL-8
- brain metastases
- mast cell
- matrix metalloprotease 2
- vascular endothelial growth factor
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Roy, Ananya
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Libard, Sylwia
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Weishaupt, Holge ...
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Gustavsson, Ida
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Uhrbom, Lene
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Hesselager, Göra ...
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Johansson, Fredr ...
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Ponten, Fredrik
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Alafuzoff, Irina
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Tchougounova, El ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Frontiers in Onc ...
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences