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  • Mercer, Louise K.Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England. (author)

Spectrum of lymphomas across different drug treatment groups in rheumatoid arthritis : a European registries collaborative project

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-08-19
  • BMJ,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-344205
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-344205URI
  • https://doi.org/10.1136/annrheumdis-2017-211623DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137151638URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background Lymphomas comprise a heterogeneous group of malignant diseases with highly variable prognosis. Rheumatoid arthritis (RA) is associated with a twofold increased risk of both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). It is unknown whether treatment with biologic disease-modifying antirheumatic drugs (bDMARDs) affect the risk of specific lymphoma subtypes.Methods Patients never exposed to (bionaïve) or ever treated with bDMARDs from 12 European biologic registers were followed prospectively for the occurrence of first ever histologically confirmed lymphoma. Patients were considered exposed to a bDMARD after having received the first dose. Lymphomas were attributed to the most recently received bDMARD.Results Among 124 997 patients (mean age 59 years; 73.7% female), 533 lymphomas were reported. Of these, 9.5% were HL, 83.8% B-cell NHL and 6.8% T-cell NHL. No cases of hepatosplenic T-cell lymphoma were observed. Diffuse large B-cell lymphoma (DLBCL) was the most frequent B-cell NHL subtype (55.8% of all B-cell NHLs). The subtype distributions were similar between bionaïve patients and those treated with tumour necrosis factor inhibitors (TNFi). For other bDMARDs, the numbers of cases were too small to draw any conclusions. Patients with RA developed more DLBCLs and less chronic lymphocytic leukaemia compared with the general population.Conclusion This large collaborative analysis of European registries has successfully collated subtype information on 533 lymphomas. While the subtype distribution differs between RA and the general population, there was no evidence of any modification of the distribution of lymphoma subtypes in patients with RA treated with TNFi compared with bionaïve patients.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Regierer, Anne C.German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany. (author)
  • Mariette, XavierUniv Paris Sud, Hop Univ Paris Sud, Dept Rheumatol, Le Kremlin Bicetre, France. (author)
  • Dixon, William G.Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England. (author)
  • Baecklund, Eva,1956-Uppsala universitet,Reumatologi(Swepub:uu)evaba786 (author)
  • Hellgren, KarinKarolinska Institutet (author)
  • Dreyer, LeneRigshosp, Gentofte Univ Hosp, Ctr Rheumatol & Spine Dis, Hellerup, Denmark.;Parker Inst, Frederiksberg, Denmark. (author)
  • Hetland, Merete LundRigshosp, Ctr Head & Orthopaed, Copenhagen Ctr Arthrit Res, DANBIO, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark. (author)
  • Cordtz, ReneRigshosp, Gentofte Univ Hosp, Ctr Rheumatol & Spine Dis, Hellerup, Denmark.;Parker Inst, Frederiksberg, Denmark. (author)
  • Hyrich, KimmeUniv Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England.;Cent Manchester NHS Fdn Trust, Manchester Acad Hlth Sci, Natl Inst Hlth Res Manchester, Musculoskeletal Biomed Res Unit, Manchester, Lancs, England. (author)
  • Strangfeld, AnjaGerman Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany. (author)
  • Zink, AngelaGerman Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany.;Charite, Berlin, Germany. (author)
  • Canhao, HelenaUniv Nova Lisboa, EpiDoC Unit, CEDOC, NOVA Med Sch, Lisbon, Portugal.;Natl Sch Publ Hlth, Lisbon, Portugal. (author)
  • Victoria Hernandez, M.Hosp Clin Barcelona, Dept Rheumatol, Barcelona, Spain. (author)
  • Tubach, FlorenceUniv Paris 06, Sorbonne Univ, Hop Pitie Salpetriere, AP HP,Dept BIOSPIM, Paris, France. (author)
  • Gottenberg, Jacques-EricCHU Strasbourg, Dept Rheumatol, Strasbourg, France. (author)
  • Morel, JacquesUniv Montpellier, Dept Rheumatol, Montpellier, France.;Teaching Hosp Lapeyronie, Montpellier, France. (author)
  • Zavada, JakubCharles Univ Prague, Fac Med 1, Inst Rheumatol, Prague, Czech Republic. (author)
  • Iannone, FlorenzoUniv Bari, Rheumatol Unit, Bari, Italy. (author)
  • Askling, JohanKarolinska Institutet (author)
  • Listing, JoachimGerman Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany. (author)
  • Univ Manchester, Arthrit Res UK Ctr Epidemiol, Manchester, Lancs, England.German Rheumatism Res Ctr, Epidemiol Unit, Berlin, Germany. (creator_code:org_t)

Related titles

  • In:Annals of the Rheumatic Diseases: BMJ76:12, s. 2025-20300003-49671468-2060

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