Search: onr:"swepub:oai:DiVA.org:uu-346369" > Reproducible diagno...
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000 | 06322naa a2200781 4500 | |
001 | oai:DiVA.org:uu-346369 | |
003 | SwePub | |
008 | 180316s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:137514950 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3463692 URI |
024 | 7 | a https://doi.org/10.1002/cyto.b.215952 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1375149502 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rawstron, Andy C.u St Jamess Inst Oncol, Leeds4 aut |
245 | 1 0 | a Reproducible diagnosis of chronic lymphocytic leukemia by flow cytometry :b An European Research Initiative on CLL (ERIC) & European Society for Clinical Cell Analysis (ESCCA) Harmonisation project |
264 | c 2018-01-17 | |
264 | 1 | b Wiley,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a The diagnostic criteria for CLL rely on morphology and immunophenotype. Current approaches have limitations affecting reproducibility and there is no consensus on the role of new markers. The aim of this project was to identify reproducible criteria and consensus on markers recommended for the diagnosis of CLL. ERIC/ESCCA members classified 14 of 35 potential markers as “required” or “recommended” for CLL diagnosis, consensus being defined as >75% and >50% agreement, respectively. An approach to validate “required” markers using normal peripheral blood was developed. Responses were received from 150 participants with a diagnostic workload >20 CLL cases per week in 23/150 (15%), 5–20 in 82/150 (55%), and <5 cases per week in 45/150 (30%). The consensus for “required” diagnostic markers included: CD19, CD5, CD20, CD23, Kappa, and Lambda. “Recommended” markers potentially useful for differential diagnosis were: CD43, CD79b, CD81, CD200, CD10, and ROR1. Reproducible criteria for component reagents were assessed retrospectively in 14,643 cases from 13 different centers and showed >97% concordance with current approaches. A pilot study to validate staining quality was completed in 11 centers. Markers considered as “required” for the diagnosis of CLL by the participants in this study (CD19, CD5, CD20, CD23, Kappa, and Lambda) are consistent with current diagnostic criteria and practice. Importantly, a reproducible approach to validate and apply these markers in individual laboratories has been identified. Finally, a consensus “recommended” panel of markers to refine diagnosis in borderline cases (CD43, CD79b, CD81, CD200, CD10, and ROR1) has been defined and will be prospectively evaluated. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng |
653 | a chronic lymphocytic leukemia | |
653 | a flow cytometry | |
653 | a diagnosis | |
700 | 1 | a Kreuzer, Karl-Antonu Universitätsklinikum Köln, Köln4 aut |
700 | 1 | a Soosapilla, Ashau Laverty Pathol, Sydney4 aut |
700 | 1 | a Spacek, Martinu Univ Hosp, Prague4 aut |
700 | 1 | a Stehlikova, Olgau Masaryk Univ, CEITEC, Brno; Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno4 aut |
700 | 1 | a Gambell, Peteru Peter MacCallum Canc Ctr, Melbourne4 aut |
700 | 1 | a McIver-Brown, Neilu Royal Bournemouth Hosp, Bournemouth4 aut |
700 | 1 | a Villamor, Neusu Hosp Clin Barcelona, Hematopathol Unit, Barcelona4 aut |
700 | 1 | a Psarra, Katherinau Evangelismos Med Ctr, Athens4 aut |
700 | 1 | a Arroz, Mariau CHLO Hosp S Francisco Xavier, Dept Clin Pathol, Flow Cytometry Lab, Lisbon4 aut |
700 | 1 | a Milani, Raffaellau Osped San Raffaele, Milan4 aut |
700 | 1 | a de la Serna, Javieru Hosp Univ 12 Octubre, Madrid4 aut |
700 | 1 | a Teresa Cedena, M.u Hosp Univ 12 Octubre, Madrid4 aut |
700 | 1 | a Jaksic, Ozrenu Dubrava Univ Hosp, Zagreb4 aut |
700 | 1 | a Nomdedeu, Josepu Hosp Santa Creu & Sant Pau, Barcelona4 aut |
700 | 1 | a Moreno, Carolu Hosp Santa Creu & Sant Pau, Barcelona4 aut |
700 | 1 | a Rigolin, Gian Matteou St Anna Univ Hosp, Ferrara4 aut |
700 | 1 | a Cuneo, Antoniou St Anna Univ Hosp, Ferrara4 aut |
700 | 1 | a Johansen, Prebenu Aalborg Univ Hosp, Dept Haematol, Clin Canc Res Ctr, Aalborg; Aalborg Univ, Dept Clin Med, Aalborg4 aut |
700 | 1 | a Johnsen, Hans E.u Aalborg Univ Hosp, Dept Haematol, Clin Canc Res Ctr, Aalborg; Aalborg Univ, Dept Clin Med, Aalborg4 aut |
700 | 1 | a Rosenquist, Richardu Karolinska Institutet,Uppsala universitet,Experimentell och klinisk onkologi4 aut0 (Swepub:uu)richrose |
700 | 1 | a Niemann, Carsten Utoftu Copenhagen Univ Hosp, Rigshosp, Copenhagen4 aut |
700 | 1 | a Kern, Wolfgangu MLL Munich Leukemia Lab, Munich4 aut |
700 | 1 | a Westerman, Davidu Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Brno4 aut |
700 | 1 | a Trneny, Mareku Univ Hosp, Prague4 aut |
700 | 1 | a Mulligan, Stephenu Laverty Pathol, Sydney4 aut |
700 | 1 | a Doubek, Michaelu Masaryk Univ, CEITEC, Brno4 aut |
700 | 1 | a Pospisilova, Sarkau Masaryk Univ, CEITEC, Brno4 aut |
700 | 1 | a Hillmen, Peteru St Jamess Inst Oncol, Leeds4 aut |
700 | 1 | a Oscier, Davidu Royal Bournemouth Hosp, Bournemouth4 aut |
700 | 1 | a Hallek, Michaelu Univ Klinikum Köln, Köln4 aut |
700 | 1 | a Ghia, Paolou Univ Vita Salute San Raffaele, Milan; IRCCS Ist Sci San Raffaele, Milan4 aut |
700 | 1 | a Montserrat, Emiliu Univ Barcelona, Hosp Clin, Dept Hematol, Barcelona4 aut |
710 | 2 | a St Jamess Inst Oncol, Leedsb Universitätsklinikum Köln, Köln4 org |
773 | 0 | t Cytometry. Part B, Clinical cytometry.d : Wileyg 94:1, s. 121-128q 94:1<121-128x 1552-4949x 1552-4957 |
856 | 4 | u https://doi.org/10.1002/cyto.b.21595y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1191241/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.21595 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-346369 |
856 | 4 8 | u https://doi.org/10.1002/cyto.b.21595 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:137514950 |
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