Development and external validation of a post-discharge bleeding risk score in patients with acute coronary syndrome: The BleeMACS score

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Development and external validation of a post-discharge bleeding risk score in patients with acute coronary syndrome : The BleeMACS score

Raposeiras-Roubin, Sergio (author): Hosp Alvaro Cunqueiro, Vigo, Spain.

Faxen, Jonas (author): Karolinska Institutet

Iniguez-Romo, Andres (author): Hosp Alvaro Cunqueiro, Vigo, Spain.

Henriques, Jose Paulo Simao (author): Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.

D'Ascenzo, Fabrizio (author): San Giovanni Battista Molinette Hosp, Turin, Italy.

Saucedo, Jorge (author): NorthShore Univ Hosp, Chicago, IL USA.

Szummer, Karolina (author): Karolinska Institutet

Jernberg, Tomas (author): Karolinska Institutet

James, Stefan K, 1964- (author): Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi

Gonzalez Juanatey, Jose Ramon (author): Clin Hosp, Santiago De Compostela, Spain.

Wilton, Stephen B. (author): Libin Cardiovasc Inst Alberta, Calgary, AB, Canada.

Kikkert, Wouter J. (author): Univ Amsterdam, Acad Med Ctr, Amsterdam, Netherlands.

Nunez-Gil, Ivan (author): San Carlos Hosp, Madrid, Spain.

Ariza-Sole, Albert (author): Bellvitge Hosp, Barcelona, Spain.

Song, Xiantao (author): Anzhen Hosp, Beijing, Peoples R China.

Alexopoulos, Dimitrios (author): Univ Patras Hosp, Patras, Greece.

Liebetrau, Christoph (author): Kerckhoff Heart & Thorax Ctr, Frankfurt, Germany.

Kawaji, Tetsuma (author): Univ Grad Sch Med, Kyoto, Japan.

Moretti, Claudio (author): San Giovanni Battista Molinette Hosp, Turin, Italy.

Huczek, Zenon (author): Univ Clin Hosp, Warsaw, Poland.

Nie, Shao-Ping (author): Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China.

Fujii, Toshiharu (author): Tokai Univ, Sch Med, Tokai, Ibaraki, Japan.

Correia, Luis (author): Hosp Sao Rafael, Salvador, BA, Brazil.

Kawashiri, Masa-aki (author): Univ Grad Sch Med, Kanazawa, Japan.

Caneiro-Queija, Berenice (author): Hosp Alvaro Cunqueiro, Vigo, Spain.

Cobas-Paz, Rafael (author): Hosp Alvaro Cunqueiro, Vigo, Spain.

Garcia Acuna, Jose Maria (author): Clin Hosp, Santiago De Compostela, Spain.

Southern, Danielle (author): Libin Cardiovasc Inst Alberta, Calgary, AB, Canada.

Alfonso, Emilio (author): San Carlos Hosp, Madrid, Spain.

Terol, Belen (author): San Carlos Hosp, Madrid, Spain.

Garay, Alberto (author): Bellvitge Hosp, Barcelona, Spain.

Zhang, Dongfeng (author): Anzhen Hosp, Beijing, Peoples R China.

Chen, Yalei (author): Anzhen Hosp, Beijing, Peoples R China.

Xanthopoulou, Ioanna (author): Univ Patras Hosp, Patras, Greece.

Osman, Neriman (author): Kerckhoff Heart & Thorax Ctr, Frankfurt, Germany.

Moellmann, Helge (author): Kerckhoff Heart & Thorax Ctr, Frankfurt, Germany.

Shiomi, Hiroki (author): Univ Grad Sch Med, Kyoto, Japan.

Giordana, Francesca (author): San Giovanni Battista Molinette Hosp, Turin, Italy.

Gaita, Fiorenzo (author): San Giovanni Battista Molinette Hosp, Turin, Italy.

Kowara, Michal (author): Univ Clin Hosp, Warsaw, Poland.

Filipiak, Krzysztof (author): Univ Clin Hosp, Warsaw, Poland.

Wang, Xiao (author): Univ Clin Hosp, Warsaw, Poland.

Yan, Yan (author): Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China.

Fan, Jing-Yao (author): Univ Clin Hosp, Warsaw, Poland.

Ikari, Yuji (author): Tokai Univ, Sch Med, Tokai, Ibaraki, Japan.

Nakahayshi, Takuya (author): Univ Grad Sch Med, Kanazawa, Japan.

Sakata, Kenji (author): Univ Grad Sch Med, Kanazawa, Japan.

Yamagishi, Masakazu (author): Univ Grad Sch Med, Kanazawa, Japan.

Kalpak, Oliver (author): Univ Clin Cardiol, Skopje, Macedonia.

Kedev, Sasko (author): Univ Clin Cardiol, Skopje, Macedonia.

Rivera-Asenjo, Daniel (author): Hosp Alvaro Cunqueiro, Vigo, Spain.

Abu-Assi, Emad (author): Hosp Alvaro Cunqueiro, Vigo, Spain.

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Karolinska Institutet Hosp Alvaro Cunqueiro, Vigo, Spain (creator_code:org_t)

ELSEVIER IRELAND LTD, 2018
2018
English.
In: International Journal of Cardiology. - : ELSEVIER IRELAND LTD. - 0167-5273 .- 1874-1754. ; 254, s. 10-15

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Accurate 1-year bleeding risk estimation after hospital discharge for acute coronary syndrome(ACS) may help clinicians guide the type and duration of antithrombotic therapy. Currently there are no predictive models for this purpose. The aim of this study was to derive and validate a simple clinical tool for bedside risk estimation of 1-year post-discharge serious bleeding in ACS patients.Methods: The risk score was derived and internally validated in the BleeMACS (Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome) registry, an observational international registry involving 15,401 patients surviving admission for ACS and undergoing percutaneous coronary intervention (PCI) from 2003 to 2014, engaging 15 hospitals from 10 countries located in America, Europe and Asia. External validation was conducted in the SWEDEHEART population, with 96,239 ACS patients underwent PCI and 93,150 without PCI.Results: Seven independent predictors of bleeding were identified and included in the BleeMACS score: age, hypertension, vascular disease, history of bleeding, malignancy, creatinine and hemoglobin. The BleeMACS risk score exhibited a C-statistic value of 0.71 (95% CI 0.68-0.74) in the derivation cohort and 0.72 (95% CI 0.67-0.76) in the internal validation sample. In the SWEDEHEART external validation cohort, the C-statistic was 0.65 (95% CI 0.64-0.66) for PCI patients and 0.63 (95% CI 0.62-0.64) for non-PCI patients. The calibration was excellent in the derivation and validation cohorts.Conclusions: The BleeMACS bleeding risk score is a simple tool useful for identifying those ACS patients at higher risk of serious 1-year post-discharge bleeding.

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By the author/editor: Raposeiras-Roubi ...; Faxen, Jonas; Iniguez-Romo, An ...; Henriques, Jose ...; D'Ascenzo, Fabri ...; Saucedo, Jorge; show more...; Szummer, Karolin ...; Jernberg, Tomas; James, Stefan K, ...; Gonzalez Juanate ...; Wilton, Stephen ...; Kikkert, Wouter ...; Nunez-Gil, Ivan; Ariza-Sole, Albe ...; Song, Xiantao; Alexopoulos, Dim ...; Liebetrau, Chris ...; Kawaji, Tetsuma; Moretti, Claudio; Huczek, Zenon; Nie, Shao-Ping; Fujii, Toshiharu; Correia, Luis; Kawashiri, Masa- ...; Caneiro-Queija, ...; Cobas-Paz, Rafae ...; Garcia Acuna, Jo ...; Southern, Daniel ...; Alfonso, Emilio; Terol, Belen; Garay, Alberto; Zhang, Dongfeng; Chen, Yalei; Xanthopoulou, Io ...; Osman, Neriman; Moellmann, Helge; Shiomi, Hiroki; Giordana, France ...; Gaita, Fiorenzo; Kowara, Michal; Filipiak, Krzysz ...; Wang, Xiao; Yan, Yan; Fan, Jing-Yao; Ikari, Yuji; Nakahayshi, Taku ...; Sakata, Kenji; Yamagishi, Masak ...; Kalpak, Oliver; Kedev, Sasko; Rivera-Asenjo, D ...; Abu-Assi, Emad; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: International Jo ...

By the university: Uppsala University; Karolinska Institutet

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Development and external validation of a post-discharge bleeding risk score in patients with acute coronary syndrome : The BleeMACS score

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