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Cerebral serotonin ...
Cerebral serotonin transporter measurements with [11C]DASB : A review on acquisition and preprocessing across 21 PET centres
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Nørgaard, Martin (author)
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Ganz, Melanie (author)
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Svarer, Claus (author)
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Feng, Ling (author)
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Ichise, Masanori (author)
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Lanzenberger, Rupert (author)
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- Lubberink, Mark (author)
- Uppsala universitet,Radiologi
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Parsey, Ramin V (author)
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Politis, Marios (author)
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Rabiner, Eugenii A (author)
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Slifstein, Mark (author)
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Sossi, Vesna (author)
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Suhara, Tetsuya (author)
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Talbot, Peter S (author)
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Turkheimer, Federico (author)
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Strother, Stephen C (author)
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Knudsen, Gitte M (author)
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(creator_code:org_t)
- 2019
- 2019
- English.
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In: Journal of Cerebral Blood Flow and Metabolism. - 0271-678X .- 1559-7016. ; 39:2, s. 210-222
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [11C]DASB for quantification of cerebral serotonin transporter binding, as an exemplary case. We highlight and quantify the impact of the remarkable variety of ways in which researchers are currently conducting their studies, while implicitly expecting generalizable results across research groups. Our review provides evidence that the foundation for a given choice of a preprocessing pipeline seems to be an overlooked aspect in modern PET neuroscience. Furthermore, we believe that a thorough testing of pipeline performance is necessary to produce reproducible research outcomes, avoiding biased results and allowing for better understanding of human brain function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Positron Emission Tomography
- [11C]DASB
- data sharing
- kinetic modeling
- preprocessing
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Nørgaard, Martin
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Ganz, Melanie
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Svarer, Claus
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Feng, Ling
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Ichise, Masanori
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Lanzenberger, Ru ...
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show more...
-
Lubberink, Mark
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Parsey, Ramin V
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Politis, Marios
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Rabiner, Eugenii ...
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Slifstein, Mark
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Sossi, Vesna
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Suhara, Tetsuya
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Talbot, Peter S
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Turkheimer, Fede ...
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Strother, Stephe ...
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Knudsen, Gitte M
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Journal of Cereb ...
- By the university
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Uppsala University