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  • Nicholson, Andrew G.Royal Brompton & Harefield Natl Hlth Serv Fdn Tru, London, England.;Imperial Coll, Natl Heart & Lung Inst, London, England. (author)

Interobserver Variation among Pathologists and Refinement of Criteria in Distinguishing Separate Primary Tumors from Intrapulmonary Metastases in Lung

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • ELSEVIER SCIENCE INC,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-349848
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-349848URI
  • https://doi.org/10.1016/j.jtho.2017.10.019DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Multiple tumor nodules are seen with increasing frequency in clinical practice. On the basis of the 2015 WHO classification of lung tumors, we assessed the reproducibility of the comprehensive histologic assessment to distinguish second primary lung cancers (SPLCs) from intrapulmonary metastases (IPMs), looking for the most distinctive histologic features. An international panel of lung pathologists reviewed a scanned sequential cohort of 126 tumors from 48 patients and recorded an agreed set of histologic features, including tumor typing and predominant pattern of adenocarcinoma, thereby opining whether the case was SPLC, IPM, or a combination thereof. Cohen kappa statistics of 0.60 on overall assessment of SPLC or IPM indicated a good agreement. Likewise, there was good agreement (kappa score 0.64, p < 0.0001) between WHO histologic pattern in individual cases and SPLC or IPM status, but the proportions diversified for histologic pattern and SPLC or IPM status (McNemar test, p < 0.0001). The strongest associations for distinguishing between SPLC and IPM were observed for nuclear pleomorphism, cell size, acinus formation, nucleolar size, mitotic rate, nuclear inclusions, intraalveolar clusters, and necrosis. Conversely, the associations for lymphocytosis, mucin content, lepidic growth, vascular invasion, macrophage response, clear cell change, acute inflammation keratinization, and emperipolesis did not reach significance with tumor extent. Comprehensive histologic assessment is recommended for distinguishing SPLC from IPM with good reproducibility among lung pathologists. In addition to main histologic type and predominant patterns of histologic subtypes, nuclear pleomorphism, cell size, acinus formation, nucleolar size, and mitotic rate strongly correlate with pathologic staging status.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Torkko, KathleenUniv Colorado, Anschutz Med Campus, Aurora, CO USA. (author)
  • Viola, PatriziaRoyal Brompton & Harefield Natl Hlth Serv Fdn Tru, London, England.;Imperial Coll, Natl Heart & Lung Inst, London, England. (author)
  • Duhig, EdwinaSullivan Nicolaides Pathol, Taringa, Qld, Australia. (author)
  • Geisinger, KimUniv Mississippi, Med Ctr, Jackson, MS 39216 USA. (author)
  • Borczuk, Alain C.Weill Cornell Med, New York, NY USA. (author)
  • Hiroshima, KenzoTokyo Womens Med Univ, Yachiyo, Japan. (author)
  • Tsao, Ming S.Princess Margaret Canc Ctr, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada. (author)
  • Warth, ArneHeidelberg Univ Hosp, Heidelberg, Germany. (author)
  • Lantuejoul, SylvieCanc Inst Leon Berard, Lyon, France. (author)
  • Russell, Prudence A.St Vincents Pathol, Fitzroy, Vic, Australia. (author)
  • Thunnissen, ErikVrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands. (author)
  • Marchevsky, AlbertoCedars Sinai Med Ctr, Los Angeles, CA 90048 USA. (author)
  • Mino-Kenudson, MariMassachusetts Gen Hosp, Boston, MA 02114 USA. (author)
  • Beasley, Mary BethMt Sinai Med Ctr, New York, NY 10029 USA. (author)
  • Botling, JohanUppsala universitet,Klinisk och experimentell patologi,Johan Botling(Swepub:uu)johanbot (author)
  • Dacic, SanjaUniv Pittsburgh, Pittsburgh, PA USA. (author)
  • Yatabe, YasushiAichi Canc Ctr, Nagoya, Aichi, Japan. (author)
  • Noguchi, MasayukiUniv Tsukuba, Tsukuba, Ibaraki, Japan. (author)
  • Travis, William D.Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA. (author)
  • Kerr, KeithAberdeen Royal Infirm, Aberdeen, Scotland. (author)
  • Hirsch, Fred R.Univ Colorado, Anschutz Med Campus, Aurora, CO USA. (author)
  • Chirieac, Lucian R.Harvard Med Sch, Boston, MA USA. (author)
  • Wistuba, Ignacio I.MD Anderson, Houston, TX USA. (author)
  • Moreira, AndreNYU, Langone Med Ctr, New York, NY USA. (author)
  • Chung, Jin-HaengSeoul Natl Univ, Bundang Hosp, Seoul, South Korea. (author)
  • Chou, Teh YingTaipei Vet Gen Hosp, Taipei, Taiwan. (author)
  • Bubendorf, LukasUniv Hosp Basel, Basel, Switzerland. (author)
  • Chen, GangFudan Univ, Zhongshan Hosp, Shanghai, Peoples R China. (author)
  • Pelosi, GiuseppeUniv Milan, Dept Oncol & Hematooncol, Milan, Italy. (author)
  • Poleri, Claudia (author)
  • Detterbeck, Frank C.Yale Univ, Dept Thorac Surg, New Haven, CT USA. (author)
  • Franklin, Wilbur A.Univ Colorado, Anschutz Med Campus, Aurora, CO USA. (author)
  • Royal Brompton & Harefield Natl Hlth Serv Fdn Tru, London, England.;Imperial Coll, Natl Heart & Lung Inst, London, England.Univ Colorado, Anschutz Med Campus, Aurora, CO USA. (creator_code:org_t)

Related titles

  • In:Journal of Thoracic Oncology: ELSEVIER SCIENCE INC13:2, s. 205-2171556-08641556-1380

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