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A prospective inves...
A prospective investigation of perceived stress, infertility-related stress, and cortisol levels in women undergoing in vitro fertilization : influence on embryo quality and clinical pregnancy rate
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- Cesta, Carolyn E. (author)
- Karolinska Institutet
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- Johansson, Anna L. V. (author)
- Karolinska Institutet
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- Hreinsson, Julius (author)
- Karolinska Univ Hosp, Dept Obstet & Gynecol, Reprod Med, Stockholm, Sweden.
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- Rodriguez-Wallberg, Kenny A. (author)
- Karolinska Institutet
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- Olofsson, Jan I. (author)
- Karolinska Institutet
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- Holte, Jan (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Carl von Linne Clin, Uppsala, Sweden ; Univ Agr Sci Uppsala, Ctr Reprod Biol Uppsala, Uppsala, Sweden; Uppsala Univ, Uppsala, Sweden.
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- Wramsby, Håkan (author)
- St Gorans Sjukhus, IVF Kliniken Stockholm, Stockholm, Sweden.
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- Wramsby, Margareta (author)
- Fertilitetsctr Stockholm, Stockholm, Sweden.
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- Cnattingius, Sven (author)
- Karolinska Institutet
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- Skalkidou, Alkistis, 1977- (author)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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- Iliadou, Anastasia Nyman (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Univ Hosp, Dept Obstet & Gynecol, Reprod Med, Stockholm, Sweden (creator_code:org_t)
- 2018-01-10
- 2018
- English.
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In: Acta Obstetricia et Gynecologica Scandinavica. - : WILEY. - 0001-6349 .- 1600-0412. ; 97:3, s. 258-268
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- IntroductionWomen undergoing fertility treatment experience high levels of stress. However, it remains uncertain if and how stress influences in vitro fertilization (IVF) cycle outcome. This study aimed to investigate whether self-reported perceived and infertility-related stress and cortisol levels were associated with IVF cycle outcomes.Material and methodsA prospective cohort of 485 women receiving fertility treatment was recruited from September 2011 to December 2013 and followed until December 2014. Data were collected by online questionnaire prior to IVF start and from clinical charts. Salivary cortisol levels were measured. Associations between stress and cycle outcomes (clinical pregnancy and indicators of oocyte and embryo quality) were measured by logistic or linear regression, adjusted for age, body mass index, education, smoking, alcohol and caffeine consumption, shiftwork and night work. ResultsUltrasound verified pregnancy rate was 26.6% overall per cycle started and 32.9% per embryo transfer. Stress measures were not associated with clinical pregnancy: when compared with the lowest categories, the adjusted odds ratio (OR) and 95% confidence interval (CI) for the highest categories of the perceived stress score was 1.04 (95% CI 0.58-1.87), infertility-related stress score was OR = 1.18 (95% CI 0.56-2.47), morning and evening cortisol was OR = 1.18 (95% CI 0.60-2.29) and OR = 0.66 (95% CI 0.34-1.30), respectively.ConclusionsPerceived stress, infertility-related stress, and cortisol levels were not associated with IVF cycle outcomes. These findings are potentially reassuring to women undergoing fertility treatment with concerns about the influence of stress on their treatment outcome.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Keyword
- In vitro fertilization
- IVF outcome
- stress
- cortisol
- embryo quality
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cesta, Carolyn E ...
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Johansson, Anna ...
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Hreinsson, Juliu ...
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Rodriguez-Wallbe ...
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Olofsson, Jan I.
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Holte, Jan
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Wramsby, Håkan
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Wramsby, Margare ...
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Cnattingius, Sve ...
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Skalkidou, Alkis ...
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Iliadou, Anastas ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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Acta Obstetricia ...
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Uppsala University
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Karolinska Institutet