Search: onr:"swepub:oai:DiVA.org:uu-350627" > Global analysis of ...
Fältnamn | Indikatorer | Metadata |
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000 | 04736naa a2200577 4500 | |
001 | oai:DiVA.org:uu-350627 | |
003 | SwePub | |
008 | 180521s2018 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:137846680 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3506272 URI |
024 | 7 | a https://doi.org/10.7717/peerj.44662 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1378466802 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Franzen, Oscaru Karolinska Institutet,Karolinska Inst, Integrated Cardio Metab Ctr, Huddinge, Sweden.4 aut |
245 | 1 0 | a Global analysis of A-to-I RNA editing reveals association with common disease variants |
264 | c 2018-03-06 | |
264 | 1 | b PeerJ,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a RNA editing modifies transcripts and may alter their regulation or function. In humans, the most common modification is adenosine to inosine (A-to-I). We examined the global characteristics of RNA editing in 4,301 human tissue samples. More than 1.6 million A-to-I edits were identified in 62% of all protein-coding transcripts. mRNA recoding was extremely rare; only 11 novel recoding sites were uncovered. Thirty single nucleotide polymorphisms from genome-wide association studies were associated with RNA editing; one that influences type 2 diabetes (rs2028299) was associated with editing in ARPIN. Twenty-five genes, including LRP11 and PLIN5, had editing sites that were associated with plasma lipid levels. Our findings provide new insights into the genetic regulation of RNA editing and establish a rich catalogue for further exploration of this process. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
653 | a RNA editing | |
653 | a Gene expression | |
653 | a Quantitative trait loci | |
653 | a RNA-seq | |
653 | a Bioinformatics | |
653 | a Biostatistics | |
700 | 1 | a Ermel, Railiu Tartu Univ Hosp, Dept Cardiac Surg, Tartu, Estonia.4 aut |
700 | 1 | a Sukhavasi, Katyayaniu Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.4 aut |
700 | 1 | a Jain, Rajeevu Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.4 aut |
700 | 1 | a Jain, Anamikau Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.4 aut |
700 | 1 | a Betsholtz, Christeru Karolinska Institutet,Uppsala universitet,Vaskulärbiologi,Karolinska Inst, Integrated Cardio Metab Ctr, Huddinge, Sweden4 aut0 (Swepub:uu)chbet517 |
700 | 1 | a Giannarelli, Chiarau Icahn Sch Med Mt Sinai, Cardiovasc Res Ctr, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.4 aut |
700 | 1 | a Kovacic, Jason C.u Icahn Sch Med Mt Sinai, Cardiovasc Res Ctr, New York, NY 10029 USA.4 aut |
700 | 1 | a Ruusalepp, Arnou Tartu Univ Hosp, Dept Cardiac Surg, Tartu, Estonia.;Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.;Clin Gene Networks AB, Stockholm, Sweden.4 aut |
700 | 1 | a Skogsberg, Josefinu Karolinska Institutet,Karolinska Inst, Dept Med Biochem & Biophys, Solna, Sweden.4 aut |
700 | 1 | a Hao, Keu Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.4 aut |
700 | 1 | a Schadt, Eric E.u Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.;Clin Gene Networks AB, Stockholm, Sweden.4 aut |
700 | 1 | a Bjoerkegren, Johan L. M.u Karolinska Institutet,Karolinska Inst, Integrated Cardio Metab Ctr, Huddinge, Sweden.;Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.;Icahn Sch Med Mt Sinai, Inst Genom & Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.;Clin Gene Networks AB, Stockholm, Sweden.4 aut |
710 | 2 | a Karolinska Institutetb Karolinska Inst, Integrated Cardio Metab Ctr, Huddinge, Sweden.4 org |
773 | 0 | t PeerJd : PeerJg 6q 6x 2167-8359 |
856 | 4 | u https://doi.org/10.7717/peerj.4466y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1208939/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.7717/peerj.4466 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-350627 |
856 | 4 8 | u https://doi.org/10.7717/peerj.4466 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:137846680 |
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