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DNA methylation hol...
DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
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- Borssén, Magnus (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden.
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- Nordlund, Jessica (author)
- Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
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- Haider, Zahra (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden.
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- Landfors, Mattias (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden.
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- Larsson, Pär (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden.
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- Kanerva, Jukka (author)
- Univ Helsinki, Cent Hosp, Childrens Hosp, Helsinki, Finland.
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- Schmiegelow, Kjeld (author)
- Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.
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- Flaegstad, Trond (author)
- Univ Tromso, Dept Pediat, Tromso, Norway.;Univ Hosp North Norway, Tromso, Norway.
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- Jonsson, Olafur Gisli (author)
- Landspitali Univ Hosp, Childrens Hosp, Pediat Hematol Oncol, Reykjavik, Iceland.
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- Frost, Britt-Marie, 1955- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Palle, Josefine, 1964- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Forestier, Erik (author)
- Umeå universitet,Medicinsk och klinisk genetik,Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden.
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- Heyman, Mats (author)
- Karolinska Institutet
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- Hultdin, Magnus (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden.
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- Lönnerholm, Gudmar, 1941- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Degerman, Sofie (author)
- Umeå universitet,Patologi,Umea Univ, Dept Med Biosci, Blg 6M,2nd Floor, SE-90185 Umea, Sweden.
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(creator_code:org_t)
- 2018-03-05
- 2018
- English.
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In: Clinical Epigenetics. - : BIOMED CENTRAL LTD. - 1868-7083 .- 1868-7075. ; 10
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Abstract
Subject headings
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- Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients.Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data.Results: Among the 137 patients that later relapsed, patients with a CIMP-profile (n = 42) at initial diagnosis had an inferior overall survival (pOS(5years) 33%) compared to CIMP+ patients (n = 95, pOS(5years) 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors.Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- DNA methylation
- BCP-ALL
- Prognosis
- CIMP
- Relapse
- Risk stratification
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Borssén, Magnus
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Nordlund, Jessic ...
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Haider, Zahra
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Landfors, Mattia ...
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Larsson, Pär
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Kanerva, Jukka
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Schmiegelow, Kje ...
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Flaegstad, Trond
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Jonsson, Olafur ...
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Frost, Britt-Mar ...
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Palle, Josefine, ...
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Forestier, Erik
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Heyman, Mats
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Hultdin, Magnus
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Lönnerholm, Gudm ...
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Degerman, Sofie
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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Clinical Epigene ...
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet