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  • Ritsinger, VivecaKarolinska Institutet (author)

Characteristics and Prognosis in Women and Men With Type 1 Diabetes Undergoing Coronary Angiography : A Nationwide Registry Report

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-02-20
  • AMER DIABETES ASSOC,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-351572
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-351572URI
  • https://doi.org/10.2337/dc17-2352DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:137819366URI
  • https://gup.ub.gu.se/publication/266499URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: To describe sex aspects on extent of coronary artery disease (CAD) and prognosis in a contemporary population with type 1 diabetes.RESEARCH DESIGN AND METHODS: All patients undergoing coronary angiography, 2001-2013, included in the Swedish Coronary Angiography and Angioplasty Registry and the Swedish National Diabetes Register as type 1 diabetes were followed for mortality until 31 December 2013. The coronary angiogram was classified into normal, one-vessel disease, two-vessel disease, three-vessel disease, and left main stem disease.RESULTS: In all, 2,776 patients (42% women) with mean age 58 years (SD 11) were followed for 7.2 years (SD 2.2). Diabetes duration was longer in women (37 14 vs. 34 +/- 14 years in men; P < 0.001), who also had more retinopathy (68% vs. 65%; P = 0.050), whereas microalbuminuria was less common (41% vs. 51%; P < 0.001). Indications for coronary angiography did not substantially differ in women and men. The extent of CAD was somewhat less severe in women (normal angiogram 23.5% vs. 19.1%, three-vessel and left main stem disease 34.5% vs. 40.4%; P = 0.002), whereas mortality did not differ (adjusted hazard ratio 1.03 [95% CI 0.88-1.20]; P = 0.754). The standard mortality ratio for women the first year was 7.49 (5.73-9.62) and for men was 4.58 (3.60-5.74).CONCLUSIONS: In patients with type 1 diabetes admitted for coronary angiography, the extent of CAD was almost similar in women and men, and total long-term mortality did not differ. Type 1 diabetes was associated with higher mortality risk in women than in men when compared with the general population. These data support that type 1 diabetes attenuates the cardiovascular risk difference seen in men and women in the general population.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Hero, ChristelGothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xheroc (author)
  • Svensson, Ann-MarieNatl Diabet Register, Ctr Registers, Gothenburg, Sweden. (author)
  • Saleh, NawzadKarolinska Institutet (author)
  • Lagerqvist, Bo,1952-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)bolager (author)
  • Eeg-Olofsson, Katarina,1968Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine(Swepub:gu)xeegka (author)
  • Norhammar, AnnaKarolinska Institutet (author)
  • Karolinska InstitutetInstitutionen för medicin (creator_code:org_t)

Related titles

  • In:Diabetes Care: AMER DIABETES ASSOC41:4, s. 876-8830149-59921935-5548

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