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Odilorhabdins, Anti...
Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site
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- Pantel, Lucile (author)
- Nosopharm, Espace Innovat 2, 110 Allee Charles Babbage, F-30000 Nimes, France
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- Florin, Tanja (author)
- Univ Illinois, Ctr Biomol Sci, Chicago, IL 60607 USA
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- Dobosz-Bartoszek, Malgorzata (author)
- Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA
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- Racine, Emilie (author)
- Nosopharm, Espace Innovat 2, 110 Allee Charles Babbage, F-30000 Nimes, France
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- Sarciaux, Matthieu (author)
- Nosopharm, Espace Innovat 2, 110 Allee Charles Babbage, F-30000 Nimes, France
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- Serri, Marine (author)
- Nosopharm, Espace Innovat 2, 110 Allee Charles Babbage, F-30000 Nimes, France
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- Houard, Jessica (author)
- Nosopharm, Espace Innovat 2, 110 Allee Charles Babbage, F-30000 Nimes, France
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- Campagne, Jean-Marc (author)
- CNRS, ENSCM, Inst Charles Gerhardt Montpellier, UMR 5253,UM, Montpellier, France
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- de Figueiredo, Renata Marcia (author)
- CNRS, ENSCM, Inst Charles Gerhardt Montpellier, UMR 5253,UM, Montpellier, France
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- Midrier, Camille (author)
- CNRS, ENSCM, Inst Charles Gerhardt Montpellier, UMR 5253,UM, Montpellier, France
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- Gaudriault, Sophie (author)
- Univ Montpellier, INRA, DGIMI, Montpellier, France
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- Givaudan, Alain (author)
- Univ Montpellier, INRA, DGIMI, Montpellier, France
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- Lanois, Anne (author)
- Univ Montpellier, INRA, DGIMI, Montpellier, France
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- Forst, Steve (author)
- Univ Wisconsin, Dept Biol Sci, POB 413, Milwaukee, WI 53201 USA
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- Aumelas, Andre (author)
- Nosopharm, Espace Innovat 2, 110 Allee Charles Babbage, F-30000 Nimes, France
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- Cotteaux-Lautard, Christelle (author)
- Aix Marseille Univ, IRBA, Fac Med, TMCD2,UMR MD1, Marseille, France
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- Bolla, Jean-Michel (author)
- Aix Marseille Univ, IRBA, Fac Med, TMCD2,UMR MD1, Marseille, France
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- Lundberg, Carina Vingsbo (author)
- Statens Serum Inst, Bacteria Parasites & Fungi, DK-2300 Copenhagen, Denmark
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- Huseby, Douglas L (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Hughes, Diarmaid, 1956- (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Villain-Guillot, Philippe (author)
- Nosopharm, Espace Innovat 2, 110 Allee Charles Babbage, F-30000 Nimes, France
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- Mankin, Alexander S. (author)
- Univ Illinois, Ctr Biomol Sci, Chicago, IL 60607 USA
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- Polikanov, Yury S. (author)
- Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA;Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60607 USA
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- Gualtieri, Maxime (author)
- Nosopharm, Espace Innovat 2, 110 Allee Charles Babbage, F-30000 Nimes, France
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(creator_code:org_t)
- CELL PRESS, 2018
- 2018
- English.
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In: Molecular Cell. - : CELL PRESS. - 1097-2765 .- 1097-4164. ; 70:1, s. 83-94
- Related links:
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http://www.cell.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Growing resistance of pathogenic bacteria and shortage of antibiotic discovery platforms challenge the use of antibiotics in the clinic. This threat calls for exploration of unconventional sources of antibiotics and identification of inhibitors able to eradicate resistant bacteria. Here we describe a different class of antibiotics, odilorhabdins (ODLs), produced by the enzymes of the non-ribosomal peptide synthetase gene cluster of the nematode-symbiotic bacterium Xenorhabdus nematophila. ODLs show activity against Gram-positive and Gram-negative pathogens, including carbapenem-resistant Enterobacteriaceae, and can eradicate infections in animal models. We demonstrate that the bactericidal ODLs interfere with protein synthesis. Genetic and structural analyses reveal that ODLs bind to the small ribosomal subunit at a site not exploited by current antibiotics. ODLs induce miscoding and promote hungry codon readthrough, amino acid misincorporation, and premature stop codon bypass. We propose that ODLs' miscoding activity reflects their ability to increase the affinity of non-cognate aminoacyl-tRNAs to the ribosome.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pantel, Lucile
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Florin, Tanja
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Dobosz-Bartoszek ...
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Racine, Emilie
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Sarciaux, Matthi ...
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Serri, Marine
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show more...
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Houard, Jessica
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Campagne, Jean-M ...
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de Figueiredo, R ...
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Midrier, Camille
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Gaudriault, Soph ...
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Givaudan, Alain
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Lanois, Anne
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Forst, Steve
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Aumelas, Andre
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Cotteaux-Lautard ...
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Bolla, Jean-Mich ...
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Lundberg, Carina ...
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Huseby, Douglas ...
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Hughes, Diarmaid ...
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Villain-Guillot, ...
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Mankin, Alexande ...
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Polikanov, Yury ...
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Gualtieri, Maxim ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Molecular Cell
- By the university
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Uppsala University