SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-352989"
 

Search: onr:"swepub:oai:DiVA.org:uu-352989" > Treatment-related s...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Mezheyeuski, ArturKarolinska Inst, Dept Oncol Pathol, Canc Ctr Karolinska, R8 03, Stockholm, Sweden;Belarusian State Med Univ, Dept Pathol, Minsk, Byelarus (author)

Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2017-11-13
  • SPRINGER,2018
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-352989
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-352989URI
  • https://doi.org/10.1007/s00428-017-2263-3DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138011447URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Claudin-2 is a trans-membrane protein-component of tight junctions in epithelial cells. Elevated claudin-2 expression has been reported in colorectal cancer (CRC). The aim of this study was to investigate the expression patterns of claudin-2 in human CRC samples and analyze its association with clinical characteristics and treatment outcome. TMAs of primary tumors from two cohorts of metastatic CRC (mCRC) were used. Claudin-2 IHC staining was evaluated in a semi-quantitative manner in different regions and cell types. Claudin-2 expression was also analyzed by immunofluorescence in primary cultures of human CRC cancer-associated fibroblasts (CAFs). Initial analyses identified previously unrecognized expression patterns of claudin-2 in CAFs of human CRC. Claudin-2 expression in CAFs of the invasive margin was associated with shorter progression-free survival. Subgroup analyses demonstrated that the survival associations occurred among cases that received 5-FU+oxaliplatin combination treatment, but not in patients receiving 5-FU +/- irinotecan. The finding was validated by analyses of the independent cohort. In summary, previously unreported stromal expression of claudin-2 in CAFs of human CRC was detected together with significant association between high claudin-2 expression in CAFs and shorter survival in 5-FU+oxaliplatin-treated mCRC patients.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Strell, CarinaKarolinska Institutet (author)
  • Hrynchyk, InaCity Clin Pathologoanat Bur, Minsk, Byelarus (author)
  • Guren, Tormod KyrreOslo Univ Hosp, Dept Oncol, Oslo, Norway;Oslo Univ Hosp, KG Jebsen Colorectal Canc Res Ctr, Oslo, Norway (author)
  • Dragomir, AncaUppsala universitet,Klinisk och experimentell patologi,Fredrik Pontén(Swepub:uu)ancadrag (author)
  • Doroshenko, TatyanaRepubl Res & Prod Ctr Transfusiol & Med Biotechno, Lab Antibodies & Cytokines Biotechnol, Minsk, Byelarus (author)
  • Pashkova, OksanaRepubl Res & Prod Ctr Transfusiol & Med Biotechno, Lab Antibodies & Cytokines Biotechnol, Minsk, Byelarus (author)
  • Gorgun, JuliaBelarusian Med Acad Postgrad Educ, Dept Gastroenterol & Nutr, Minsk, Byelarus (author)
  • Ruksha, KseniyaNN Alexandrov Natl Canc Ctr Belarus, Minsk, Byelarus (author)
  • Pfeiffer, PerUniv Southern Denmark, Dept Oncol, Odense, Denmark (author)
  • Kure, Elin H.Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, Oslo, Norway (author)
  • Sorbye, HalfdanHaukeland Hosp, Dept Oncol, Bergen, Norway (author)
  • Edler, DavidKarolinska Univ Hosp Solna, Dept Mol Med & Surg, S-17176 Stockholm, Sweden (author)
  • Martling, AnnaKarolinska Institutet (author)
  • Glimelius, BengtUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)bengglim (author)
  • Ostman, ArneKarolinska Institutet (author)
  • Portyanko, AnnaBelarusian State Med Univ, Dept Pathol, Minsk, Byelarus (author)
  • Karolinska InstitutetKarolinska Inst, Dept Oncol Pathol, Canc Ctr Karolinska, R8 03, Stockholm, Sweden;Belarusian State Med Univ, Dept Pathol, Minsk, Byelarus (creator_code:org_t)

Related titles

  • In:Virchows Archiv: SPRINGER472:3, s. 395-4050945-63171432-2307

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view