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Body size and risk ...
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Andersen, Kasper,1974-Uppsala University,Uppsala universitet,Kardiovaskulär epidemiologi
(author)
Body size and risk of atrial fibrillation : a cohort study of 1.1 million young men
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2017-12-25
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WILEY,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-353116
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-353116URI
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https://doi.org/10.1111/joim.12717DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137936667URI
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https://lup.lub.lu.se/record/ebccfbf6-0184-4356-b0c2-f7a11c5a1213URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Whilst tall stature has been related to lower risk of vascular disease, it has been proposed as a risk factor for atrial fibrillation. Little is known about other anthropometric measures and their joint effects on risk of atrial fibrillation.Objectives: We aim to investigate associations and potential joint effects of height, weight, body surface area (BSA) and body mass index (BMI) with risk of atrial fibrillation.Methods: In a cohort covering 1 153 151 18-year-old men participating in the Swedish military conscription (1972-1995), Cox regression was used to investigate associations of height, weight, BSA and BMI with risk of atrial fibrillation.Results: During a median of 26.3 years of follow-up, higher height was associated with higher risk of atrial fibrillation (hazard ratio [HR] 2.80; 95% CI 2.63-2.98; for 5th vs. 1st quintile) and so was larger BSA (HR 3.05; 95% CI 2.82-3.28; for 5th vs. 1st quintile). Higher weight and BMI were to a lesser extent associated with risk of atrial fibrillation (BMI: 1.42; 95% CI 1.33-1.52, for 5th vs. 1st quintile). We found a multiplicative joint effect of height and weight. Adjusting for muscle strength, exercise capacity and diseases related to atrial fibrillation attenuated these measures.Conclusions: Higher height and weight are strongly associated with higher risk of atrial fibrillation. These associations are multiplicative and independent of each other and are summarized in a strong association of body surface area with risk of atrial fibrillation. The mechanisms remain unknown but may involve increased atrial volume load with larger body size.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Rasmussen, F.Lund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine(Swepub:lu)fi6117ra
(author)
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Neovius, M.Karolinska Institute,Karolinska Institutet
(author)
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Tynelius, P.Stockholm County Council,Karolinska Institutet
(author)
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Sundström, JohanUppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital(Swepub:uu)johasund
(author)
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Uppsala universitetKardiovaskulär epidemiologi
(creator_code:org_t)
Related titles
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In:Journal of Internal Medicine: WILEY283:4, s. 346-3550954-68201365-2796
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