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The MINDVIEW project :
The MINDVIEW project : First results
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- Benlloch, Jose M. (author)
- Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain
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- Gonzalez, Antonio J. (author)
- Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain
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- Pani, Roberto (author)
- Sapienza Univ Rome, Dept Mol Med, Rome, Italy
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- Preziosi, Enrico (author)
- Sapienza Univ Rome, Dept Mol Med, Rome, Italy
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- Jackson, Carl (author)
- SensL Technol, Cork, Ireland
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- Murphy, John (author)
- SensL Technol, Cork, Ireland
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- Barbera, Julio (author)
- Oncovision, Valencia, Spain
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- Correcher, Carlos (author)
- Oncovision, Valencia, Spain
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- Aussenhofer, Sebastian (author)
- NORAS MRI Prod GmbH, Hochberg, Germany
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- Gareis, Daniel (author)
- NORAS MRI Prod GmbH, Hochberg, Germany
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- Visvikis, Dimitris (author)
- Univ Bretagne Occidentale, INSERM, UMR1101, LaTIM, Brest, France
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- Bert, Julien (author)
- Univ Bretagne Occidentale, INSERM, UMR1101, LaTIM, Brest, France
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- Langstrom, Bengt (author)
- BENCAR, Uppsala, Sweden
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- Farde, Lars (author)
- Karolinska Institutet
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- Toth, Miklos (author)
- Karolinska Institutet
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- Haggkvist, Jenny (author)
- Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden;Stockholm Cty Council, Stockholm, Sweden
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- Caixeta, Fabio Viegas (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Kullander, Klas, 1966- (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
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- Somlai-Schweiger, Ian (author)
- Tech Univ Munich, Dept Nucl Med, Munich, Germany
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- Schwaiger, Markus (author)
- Tech Univ Munich, Dept Nucl Med, Munich, Germany
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(creator_code:org_t)
- 2020-01-01
- 2018
- English.
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In: European psychiatry. - : Cambridge University Press (CUP). - 0924-9338 .- 1778-3585. ; 50, s. 21-27
- Related links:
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https://riunet.upv.e...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from 11C-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that 11C-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naïve, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- Schizophrenia
- Positron Emission Tomography
- Silicon photomultipliers and magnetic resonance
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Benlloch, Jose M ...
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Gonzalez, Antoni ...
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Pani, Roberto
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Preziosi, Enrico
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Jackson, Carl
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Murphy, John
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Barbera, Julio
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Correcher, Carlo ...
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Aussenhofer, Seb ...
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Gareis, Daniel
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Visvikis, Dimitr ...
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Bert, Julien
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Langstrom, Bengt
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Farde, Lars
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Toth, Miklos
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Haggkvist, Jenny
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Caixeta, Fabio V ...
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Kullander, Klas, ...
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Somlai-Schweiger ...
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Schwaiger, Marku ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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European psychia ...
- By the university
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Uppsala University
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Karolinska Institutet