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  • Vallianatou, TheodosiaUppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab (author)

A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • Elsevier BV,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-353358
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-353358URI
  • https://doi.org/10.1016/j.neuroimage.2018.01.013DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138119051URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • There is a high need to develop quantitative imaging methods capable of providing detailed brain localization information of several molecular species simultaneously. In addition, extensive information on the effect of the blood-brain barrier on the penetration, distribution and efficacy of neuroactive compounds is required. Thus, we have developed a mass spectrometry imaging method to visualize and quantify the brain distribution of drugs with varying blood-brain barrier permeability. With this approach, we were able to determine blood-brain barrier transport of different drugs and define the drug distribution in very small brain structures (e.g., choroid plexus) due to the high spatial resolution provided. Simultaneously, we investigated the effect of drug-drug interactions by inhibiting the membrane transporter multidrug resistance 1 protein. We propose that the described approach can serve as a valuable analytical tool during the development of neuroactive drugs, as it can provide physiologically relevant information often neglected by traditional imaging technologies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Strittmatter, NicoleAstraZeneca, IMED Biotech Unit, Pathol Sci Drug Safety & Metab, Cambridge, England (author)
  • Nilsson, AnnaUppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab(Swepub:uu)annil134 (author)
  • Shariatgorji, MohammadrezaUppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab(Swepub:uu)mohsh560 (author)
  • Hamm, GregoryAstraZeneca, IMED Biotech Unit, Pathol Sci Drug Safety & Metab, Cambridge, England (author)
  • Pereira, MarcelaKarolinska Institutet (author)
  • Källback, PatrikUppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab(Swepub:uu)joaka138 (author)
  • Svenningsson, PerKarolinska Institutet (author)
  • Karlgren, MariaUppsala universitet,Institutionen för farmaci(Swepub:uu)marka263 (author)
  • Goodwin, Richard J. A.AstraZeneca, IMED Biotech Unit, Pathol Sci Drug Safety & Metab, Cambridge, England (author)
  • Andrén, Per E.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Science for Life Laboratory, SciLifeLab(Swepub:uu)perandre (author)
  • Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)

Related titles

  • In:NeuroImage: Elsevier BV172, s. 808-8161053-81191095-9572

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