SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-355966"
 

Search: onr:"swepub:oai:DiVA.org:uu-355966" > Phytoconstituents w...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Aronsson, PerGothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)

Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis.

  • Article/chapterEnglish2016

Publisher, publication year, extent ...

  • 2016-01-15
  • MDPI AG,2016
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-355966
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355966URI
  • https://doi.org/10.3390/diseases4010003DOI
  • https://gup.ub.gu.se/publication/246744URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8'-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3'-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520-82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL). The radical scavenging activity of the isolated constituents (1-5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Munissi, Joan J E (author)
  • Gruhonjic, AmraGothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology (author)
  • Fitzpatrick, Paul A.Gothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xfitpa (author)
  • Landberg, GöranGothenburg University,Göteborgs universitet,Sahlgrenska Cancer Center(Swepub:gu)xlgora (author)
  • Nyandoro, Stephen S (author)
  • Erdelyi, Mate,1975-Gothenburg University,Göteborgs universitet,Svenskt NMR-centrum vid Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Swedish NMR Centre at Göteborg University,Department of Chemistry and Molecular Biology(Swepub:gu)xerdma (author)
  • Göteborgs universitetInstitutionen för kemi och molekylärbiologi (creator_code:org_t)

Related titles

  • In:Diseases (Basel, Switzerland): MDPI AG4:12079-9721

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view