Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus

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Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus

Pyykko, Okko T. (author): Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland

Nerg, Ossi (author): Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

Niskasaari, Hanna-Mari (author): Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland

Niskasaari, Timo (author): Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland

Koivisto, Anne M. (author): Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

Hiltunen, Mikko (author): Univ Eastern Finland, Inst Biomed, Dept Neurol, Kuopio Univ Hosp, Kuopio, Finland

Pihlajamaki, Jussi (author): Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Dept Clin Nutr, Kuopio, Finland;Kuopio Univ Hosp, Clin Nutr & Obes Ctr, Kuopio, Finland

Rauramaa, Tuomas (author): Kuopio Univ Hosp, Dept Pathol, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Pathol, Kuopio, Finland

Kojoukhova, Maria (author): Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland

Alafuzoff, Irina (author): Uppsala universitet,Klinisk och experimentell patologi,Irina Alafuzoff

Soininen, Hilkka (author): Kuopio Univ Hosp, Neurol NeuroCtr, Kuopio, Finland;Univ Eastern Finland, Inst Clin Med Neurol, Kuopio, Finland

Jaaskelainen, Juha E. (author): Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland

Leinonen, Ville (author): Kuopio Univ Hosp, Neurosurg NeuroCtr, Kuopio, Finland

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ELSEVIER SCIENCE INC, 2018
2018
English.
In: World Neurosurgery. - : ELSEVIER SCIENCE INC. - 1878-8750 .- 1878-8769. ; 112, s. E624-E631

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

OBJECT: To investigate the incidence, comorbidities, mortality, and causes of death in idiopathic normal pressure hydrocephalus (iNPH). METHODS: A cohort of 536 patients with possible NPH from a defined population with a median follow-up time of 5.1 years, (range 0.04-19.9 years) was included in the study. Patients were evaluated by brain imaging and intraventricular pressure monitoring, with a brain biopsy specimen immunostained against amyloid-beta and hyper-phosphorylated tau. Hospital records were reviewed for vascular diseases and type 2 diabetes mellitus (T2DM). Death certificates and yearly population of the catchment area were obtained from national registries. RESULTS: A total of 283 patients had a clinical diagnosis of iNPH, leading to a median annual incidence of 1.58 iNPH patients per 100,000 inhabitants (range, 0.8-4.5). Alzeimer disease-related brain biopsy findings were less frequent in iNPH patients than in non-iNPH patients (P < 0.05). An overrepresentation of hypertension (52% vs. 33%, P < 0.001) and T2DM (23% vs. 13%, P = 0.002) was noted in iNPH patients. Age (hazard ratio [HR] 1.04/year, 95% confidence interval [CI] 1.03-1.06, P< 0.001) and T2DM (HR 1.63, 95% CI 1.23-2.16, P < 0.001) increased the risk of death in the iNPH patients and in the total population. iNPH was associated with decreased risk of death (HR 0.63, 95% CI 0.50-0.78, P < 0.001). The most frequent causes of death were cardiovascular and cerebrovascular disease. Dementia as a cause of death was more common in non-iNPH patients (27% vs. 10%, P < 0.001). CONCLUSIONS: Hypertension and T2DM are common in iNPH and the latter causes excess mortality in the affected patients.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Keyword

Cause of death
Comorbidity
Incidence
Mortality
Normal pressure hydrocephalus
Survival
Patologi
Pathology

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By the author/editor: Pyykko, Okko T.; Nerg, Ossi; Niskasaari, Hann ...; Niskasaari, Timo; Koivisto, Anne M ...; Hiltunen, Mikko; show more...; Pihlajamaki, Jus ...; Rauramaa, Tuomas; Kojoukhova, Mari ...; Alafuzoff, Irina; Soininen, Hilkka; Jaaskelainen, Ju ...; Leinonen, Ville; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Clinical Laborat ...

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By the university: Uppsala University

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