Search: onr:"swepub:oai:DiVA.org:uu-357394" >
Neuronal atlas of t...
Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types
-
- Haring, Martin (author)
- Karolinska Institutet
-
- Zeisel, Amit (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden
-
- Hochgerner, Hannah (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden
-
show more...
-
- Rinwa, Puneet (author)
- Karolinska Institutet
-
- Jakobsson, Jon E. T. (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
-
- Lonnerberg, Peter (author)
- Karolinska Institutet
-
- La Manno, Gioele (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden
-
- Sharma, Nilesh (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Div Mol Neurobiol, Stockholm, Sweden
-
- Borgius, Lotta (author)
- Karolinska Institutet
-
- Kiehn, Ole (author)
- Karolinska Institutet
-
- Lagerström, Malin C. (author)
- Uppsala universitet,Genetisk utvecklingsbiologi
-
- Linnarsson, Sten (author)
- Karolinska Institutet
-
- Ernfors, Patrik (author)
- Karolinska Institutet
-
show less...
-
(creator_code:org_t)
- 2018-04-23
- 2018
- English.
-
In: Nature Neuroscience. - : NATURE PUBLISHING GROUP. - 1097-6256 .- 1546-1726. ; 21:6, s. 869-880
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- The dorsal horn of the spinal cord is critical to processing distinct modalities of noxious and innocuous sensation, but little is known of the neuronal subtypes involved, hampering efforts to deduce principles governing somatic sensation. Here we used single-cell RNA sequencing to classify sensory neurons in the mouse dorsal horn. We identified 15 inhibitory and 15 excitatory molecular subtypes of neurons, equaling the complexity in cerebral cortex. Validating our classification scheme in vivo and matching cell types to anatomy of the dorsal horn by spatial transcriptomics reveals laminar enrichment for each of the cell types. Neuron types, when combined, define a multilayered organization with like neurons layered together. Employing our scheme, we find that heat and cold stimuli activate discrete sets of both excitatory and inhibitory neuron types. This work provides a systematic and comprehensive molecular classification of spinal cord sensory neurons, enabling functional interrogation of sensory processing.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Haring, Martin
-
Zeisel, Amit
-
Hochgerner, Hann ...
-
Rinwa, Puneet
-
Jakobsson, Jon E ...
-
Lonnerberg, Pete ...
-
show more...
-
La Manno, Gioele
-
Sharma, Nilesh
-
Borgius, Lotta
-
Kiehn, Ole
-
Lagerström, Mali ...
-
Linnarsson, Sten
-
Ernfors, Patrik
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Bioinformatics a ...
- Articles in the publication
-
Nature Neuroscie ...
- By the university
-
Uppsala University
-
Karolinska Institutet