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Briaviolides K-N, N...
Briaviolides K-N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum
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- Xu, Jing-Hao (author)
- Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 94450, Taiwan;Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan
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- Lai, Kuei-Hung (author)
- Uppsala universitet,Farmakognosi,Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan
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- Su, Yin-Di (author)
- Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan;Ind Technol Res Inst, Greenhouse Syst Technol Ctr, Cent Reg Campus, Nantou 54041, Taiwan
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- Chang, Yu-Chia (author)
- Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan;Ind Technol Res Inst, Greenhouse Syst Technol Ctr, Cent Reg Campus, Nantou 54041, Taiwan;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan
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- Peng, Bo-Rong (author)
- Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan;Natl Sun Yat Sen Univ, Doctoral Degree Program Marine Biotechnol, Kaohsiung 80424, Taiwan;Acad Sinica, Doctoral Degree Program Marine Biotechnol, Taipei 11529, Taiwan
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- Backlund, Anders, 1965- (author)
- Uppsala universitet,Farmakognosi
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- Wen, Zhi-Hong (author)
- Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan
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- Sung, Ping-Jyun (author)
- Natl Dong Hwa Univ, Grad Inst Marine Biol, Pingtung 94450, Taiwan;Natl Museum Marine Biol & Aquarium, Planning & Res Div, Pingtung 94450, Taiwan;Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 80424, Taiwan;China Med Univ Hosp, Chinese Med Res & Dev Ctr, Taichung 40447, Taiwan;Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 80708, Taiwan
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(creator_code:org_t)
- 2018-02-27
- 2018
- English.
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In: Marine Drugs. - : MDPI. - 1660-3397. ; 16:3
- Related links:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Four new briarane diterpenoids, briaviolides K-N (1-4), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 1-4 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Keyword
- Briareum violaceum
- briarane
- briaviolide
- iNOS
- COX-2
- ChemGPS-NP
Publication and Content Type
- ref (subject category)
- art (subject category)
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