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Randomized controll...
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Solheim, N.Lovisenberg Diakonal Hosp, Oslo, Norway;Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway
(author)
Randomized controlled trial of intra-articular ketorolac on pain and inflammation after minor arthroscopic knee surgery
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-03-07
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Wiley,2018
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-358365
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-358365URI
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https://doi.org/10.1111/aas.13104DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Ketorolac is an effective non-steroidal anti-inflammatory drug, commonly used with local anaesthetics as part of local infiltration analgesia protocols following orthopaedic surgery. However, systemic uptake and drug action may be the major mechanism after local infiltration. The aims of this project were to study the effects of a small, systemically ineffective dose of ketorolac given intra-articularly for post-operative pain and also to study synovial inflammatory biomarkers. We investigated whether ketorolac affects pro-inflammatory biomarkers in an invitro model, as well.Methods: In this placebo-controlled, blind, randomized study, we analysed intra-articular ketorolac (5mg) in ambulatory minor knee surgery patients with moderate or severe pain (n=44). We assessed post-operative pain intensity (n=44) and analysed microdialysis samples taken from knee synovial tissue every 20min (n=34). We also tested cyclooxygenase-independent effects of ketorolac in synovial cells stimulated by prostaglandin E-2 and chondroitin sulphate invitro.Results: Intra-articular ketorolac (5mg) administration did not reduce pain or synovial pro-inflammatory cytokines CXCL1, IL-8, and MCP-1, 0-120min after knee arthroscopy. Female gender was a risk factor for moderate or severe pain (relative risk 1.45, 95% confidence interval 1.04-2.01). Paradoxically, ketorolac increased the release of CXCL1 and IL-8 in prostaglandin E-2 and chondroitin sulphate-stimulated synovial cells invitro.Conclusion: Ketorolac prescribed at a low dose intra-articularly does not produce any detectable analgesic effect after minor knee surgery.
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Gregersen, I.Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway;Oslo Univ Hosp, Res Inst Internal Med, Oslo, Norway
(author)
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Halvorsen, B.Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway;Oslo Univ Hosp, Res Inst Internal Med, Oslo, Norway
(author)
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Bjerkeli, V.Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway;Oslo Univ Hosp, Res Inst Internal Med, Oslo, Norway
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Stubhaug, A.Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway;Oslo Univ Hosp, Div Emergencies & Crit Care, Dept Pain Med & Res, Oslo, Norway
(author)
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Gordh, TUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)torsgord
(author)
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Rosseland, L. A.Univ Oslo, Inst Clin Med, Fac Med, Oslo, Norway;Oslo Univ Hosp, Div Emergencies & Crit Care, Dept Res & Dev, Oslo, Norway
(author)
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Lovisenberg Diakonal Hosp, Oslo, Norway;Univ Oslo, Inst Clin Med, Fac Med, Oslo, NorwayUniv Oslo, Inst Clin Med, Fac Med, Oslo, Norway;Oslo Univ Hosp, Res Inst Internal Med, Oslo, Norway
(creator_code:org_t)
Related titles
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In:Acta Anaesthesiologica Scandinavica: Wiley62:6, s. 829-8380001-51721399-6576
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