Search: onr:"swepub:oai:DiVA.org:uu-359267" >
Survival and Late E...
-
Vrooman, Lynda M.Dana Farber Boston Childrens Canc & Blood Disorde, Dept Pediat, 450 Brookline Ave, Boston, MA 02215 USA
(author)
Survival and Late Effects after Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancy at Less than Three Years of Age
- Article/chapterEnglish2017
Publisher, publication year, extent ...
-
Elsevier BV,2017
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-359267
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-359267URI
-
https://doi.org/10.1016/j.bbmt.2017.04.017DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:136354322URI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Very young children undergoing hematopoietic cell transplantation (HCT) are a unique and vulnerable population. We analyzed outcomes of 717 patients from 117 centers who survived relapse free for year after allogeneic myeloablative HCT for hematologic malignancy at <3 years of age, between 1987 and 2012. The median follow-up was 8.3 years (range, 1.0 to 26.4 years); median age at follow-up was 9 years (range, 2 to 29 years). Ten-year overall and relapse-free survival were 87% (95% confidence interval [CI], 85% to 90%) and 84% (95% CI, 81% to 87%). Ten-year cumulative incidence of relapse was 11% (95% CI, 9% to 13%). Of 84 deaths, relapse was the leading cause (43%). Chronic graft-versus-host-disease 1 year after HCT was associated with increased risk of mortality (hazard ratio [HR], 2.1; 95% CI, 1.3 to 3.3; P=.0018). Thirty percent of patients experienced >= 1 organ toxicity/late effect >1 year after HCT. The most frequent late effects included growth hormone deficiency/growth disturbance (10-year cumulative incidence, 23%; 95% CI, 19% to 28%), cataracts (18%; 95% CI, 15% to 22%), hypothyroidism (13%; 95% CI, 10% to 16%), gonadal dysfunction/infertility requiring hormone replacement (3%; 95% CI, 2% to 5%), and stroke/seizure (3%; 95% CI, 2% to 5%). Subsequent malignancy was reported in 3.6%. In multivariable analysis, total body irradiation (TBI) was predictive of increased risk of cataracts (HR, 17.2; 95% CI, 7.4 to 39.8; P <.001), growth deficiency (HR, 3.5; 95% CI, 2.2 to 5.5; P <.001), and hypothyroidism (HR, 5.3; 95% CI, 3.0 to 9.4; P <.001). In summary, those who survived relapse free year after HCT for hematologic malignancy at <3 years of age had favorable overall survival. Chronic graft-versus host-disease and TBI were associated with adverse outcomes. Future efforts should focus on reducing the risk of relapse and late effects after HCT at early age.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Millard, Heather R.Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA
(author)
-
Brazauskas, RutaMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Div Biostat, Inst Hlth & Soc, Milwaukee, WI 53226 USA
(author)
-
Majhail, Navneet S.Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA
(author)
-
Battiwalla, MinooNHLBI, Hematol Branch, Bethesda, MD 20892 USA
(author)
-
Flowers, Mary E.Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
(author)
-
Savani, Bipin N.Vanderbilt Univ, Med Ctr, Div Hematol Oncol, Dept Med, Nashville, TN 37235 USA
(author)
-
Akpek, GorgunRush Univ, Med Ctr, Dept Internal Med, Stem Cell Transplantat & Cell Therapy, Chicago, IL 60612 USA
(author)
-
Aljurf, MahmoudKing Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia
(author)
-
Bajwa, RajinderNationwide Childrens Hosp, Div Hematol Oncol BMT, Columbus, OH USA
(author)
-
Baker, K. ScottFred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
(author)
-
Beitinjaneh, AmerUniv Miami, Div Hematol & Oncol, Miami, FL USA
(author)
-
Bitan, MenachemTel Aviv Sourasky Med Ctr, Dept Pediat Hematol Oncol, Tel Aviv, Israel
(author)
-
Buchbinder, DavidChildrens Hosp Orange Cty, Div Hematol, Orange, CA 92668 USA
(author)
-
Chow, EricFred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
(author)
-
Dandoy, ChristopherCincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplant & Immune Deficiency, Cincinnati, OH 45229 USA
(author)
-
Dietz, Andrew C.Univ Southern Calif, Childrens Hosp Los Angeles, Div Hematol Oncol, Blood & Marrow Transplantat, Los Angeles, CA USA
(author)
-
Diller, LisaDana Farber Boston Childrens Canc & Blood Disorde, Dept Pediat, 450 Brookline Ave, Boston, MA 02215 USA
(author)
-
Gale, Robert PeterImperial Coll London, Hematol Res Ctr, Dept Med, Div Expt Med, London, England
(author)
-
Hashmi, Shahrukh K.Mayo Clin, Div Hematol, Dept Internal Med, Rochester, MN USA
(author)
-
Hayashi, RobertiWashington Univ, Sch Med, Div Pediat Hematol Oncol, Dept Pediat, St Louis, MO USA
(author)
-
Hematti, PeimanUniv Wisconsin Hosp & Clin, Div Hematol Oncol Bone Marrow Transplantat, Dept Med, Madison, WI 53792 USA
(author)
-
Kamble, Rammurti T. fBaylor Coll Med, Div Hematol & Oncol, Ctr Cell & Gene Therapy, Houston, TX 77030 USA
(author)
-
Kasow, Kimberly A.Univ North Carolina Chapel Hill, Div Hematol Oncol, Dept Pediat, Chapel Hill, NC USA
(author)
-
Kletzel, MorrisAnn & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Dept Pediat, Chicago, IL 60611 USA
(author)
-
Lazarus, Hillard M.Univ Hosp Cleveland, Med Ctr, Div Hematol & Oncol, Seidman Canc Ctr, Cleveland, OH 44106 USA
(author)
-
Malone, Adriana K.Icahn Sch Med Mt Sinai, Div Hematol Oncol, Tisch Canc Inst, New York, NY 10029 USA
(author)
-
Marks, David I.Univ Hosp Bristol NHS Trust, Adult Bone Marrow Transplant, Bristol, Avon, England
(author)
-
O'Brien, Tracey A.Sydney Childrens Hosp, Kids Canc Ctr, Blood & Marrow Transplant Program, Sydney, NSW, Australia
(author)
-
Olsson, RichardKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Div Therapeut Immunol, Dept Lab Med, Stockholm, Sweden(Swepub:uu)riols677
(author)
-
Ringden, OlleKarolinska Institutet
(author)
-
Seo, SachikoEast Hosp, Natl Canc Res Ctr, Kashiwa, Chiba, Japan
(author)
-
Steinberg, AmirIcahn Sch Med Mt Sinai, Div Hematol Oncol, Tisch Canc Inst, New York, NY 10029 USA
(author)
-
Yu, Lolie C.Louisiana State Univ, Childrens Hosp, Med Ctr, Div Hematol Oncol,Ctr Canc & Blood Disorders, New Orleans, LA USA
(author)
-
Warwick, AnneUniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA
(author)
-
Shaw, BronwenMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA
(author)
-
Duncan, ChristineDana Farber Boston Childrens Canc & Blood Disorde, Dept Pediat, 450 Brookline Ave, Boston, MA 02215 USA
(author)
-
Dana Farber Boston Childrens Canc & Blood Disorde, Dept Pediat, 450 Brookline Ave, Boston, MA 02215 USAMed Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA
(creator_code:org_t)
Related titles
-
In:Biology of blood and marrow transplantation: Elsevier BV23:8, s. 1327-13341083-87911523-6536
Internet link
Find in a library
To the university's database
- By the author/editor
-
Vrooman, Lynda M ...
-
Millard, Heather ...
-
Brazauskas, Ruta
-
Majhail, Navneet ...
-
Battiwalla, Mino ...
-
Flowers, Mary E.
-
show more...
-
Savani, Bipin N.
-
Akpek, Gorgun
-
Aljurf, Mahmoud
-
Bajwa, Rajinder
-
Baker, K. Scott
-
Beitinjaneh, Ame ...
-
Bitan, Menachem
-
Buchbinder, Davi ...
-
Chow, Eric
-
Dandoy, Christop ...
-
Dietz, Andrew C.
-
Diller, Lisa
-
Gale, Robert Pet ...
-
Hashmi, Shahrukh ...
-
Hayashi, Roberti
-
Hematti, Peiman
-
Kamble, Rammurti ...
-
Kasow, Kimberly ...
-
Kletzel, Morris
-
Lazarus, Hillard ...
-
Malone, Adriana ...
-
Marks, David I.
-
O'Brien, Tracey ...
-
Olsson, Richard
-
Ringden, Olle
-
Seo, Sachiko
-
Steinberg, Amir
-
Yu, Lolie C.
-
Warwick, Anne
-
Shaw, Bronwen
-
Duncan, Christin ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
- Articles in the publication
-
Biology of blood ...
- By the university
-
Uppsala University
-
Karolinska Institutet