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Environmental peanu...
Environmental peanut exposure increases the risk of peanut sensitization in high-risk children
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- Brough, H. A. (author)
- Kings Coll London, Guys Hosp, Sch Life Course Sci, Paediat Allergy Grp,Dept Women & Childrens Heath, London, England;Guys & St Thomass NHS Fdn Trust, Childrens Allergy Serv, London, England;Kings Coll London, Guys Hosp, Sch Immunol & Microbial Sci, Paediat Allergy Grp, London, England
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- Kull, I. (author)
- Karolinska Institutet
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- Richards, K. (author)
- Kings Coll London, Guys Hosp, Sch Life Course Sci, Paediat Allergy Grp,Dept Women & Childrens Heath, London, England;Kings Coll London, Guys Hosp, Sch Immunol & Microbial Sci, Paediat Allergy Grp, London, England
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- Hallner, E. (author)
- Karolinska Institutet
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- Söderhäll, C. (author)
- Karolinska Institutet
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- Douiri, A. (author)
- Kings Coll London, Div Hlth & Social Care Res, London, England
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- Penagos, M. (author)
- Kings Coll London, Guys Hosp, Sch Life Course Sci, Paediat Allergy Grp,Dept Women & Childrens Heath, London, England;Kings Coll London, Guys Hosp, Sch Immunol & Microbial Sci, Paediat Allergy Grp, London, England
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- Melen, E. (author)
- Karolinska Institutet
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- Bergström, A. (author)
- Karolinska Institutet
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- Turcanu, V. (author)
- Kings Coll London, Guys Hosp, Sch Life Course Sci, Paediat Allergy Grp,Dept Women & Childrens Heath, London, England;Kings Coll London, Guys Hosp, Sch Immunol & Microbial Sci, Paediat Allergy Grp, London, England
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- Wickman, Magnus (author)
- Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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- Lack, G. (author)
- Kings Coll London, Guys Hosp, Sch Life Course Sci, Paediat Allergy Grp,Dept Women & Childrens Heath, London, England;Guys & St Thomass NHS Fdn Trust, Childrens Allergy Serv, London, England;Kings Coll London, Guys Hosp, Sch Immunol & Microbial Sci, Paediat Allergy Grp, London, England
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(creator_code:org_t)
- 2018-03-23
- 2018
- English.
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In: Clinical and Experimental Allergy. - : WILEY. - 0954-7894 .- 1365-2222. ; 48:5, s. 586-593
- Related links:
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https://kclpure.kcl....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: High household peanut consumption is associated with the development of peanut allergy, especially when peanut allergic cases are compared against atopic controls; thus, environmental peanut exposure (EPE) may be a risk factor for peanut sensitization and allergy. In this study, we explored the relationship between EPE and school-age peanut sensitization in a population-based cohort.Methods: Maternal bed dust was collected postnatally, and EPE was quantified using a polyclonal peanut ELISA. Peanut sensitization was assessed by specific IgE to peanut extract and sIgE to peanut protein component allergens Ara h 1, 2 or 3 >= 0.35kU/L (primary peanut sensitization). Initial nested case-control analysis was performed comparing peanut-sensitized cases against high-risk controls (matched for parental atopy) (n = 411) using a conditional regression analysis. This was followed by whole cohort analysis (n = 1878) comparing EPE against peanut sIgE sensitization at ages 4 and 8 years using generalized estimating equations and against primary peanut sensitization at age 8 years using a logistic regression model. Finally, a subgroup analysis was performed comparing the impact of EPE in peanut-sensitized vs egg-sensitized, peanut-tolerant individuals using logistic regression analysis. Levels of EPE were compared between groups using the Mann-Whitney U test.Results: In the nested case-control analysis, a higher level of EPE around birth was associated with peanut-specific IgE sensitization at age 4 years (OR=1.41, 95% CI:1.05-1.90) and primary peanut sensitization at age 8 years (OR=2.11, 95% CI:1.38-3.22) compared against high-risk controls. When the whole BAMSE cohort was assessed, EPE was no longer associated with peanut sensitization; however, on subgroup analysis, EPE was associated with primary peanut sensitization when compared against egg-sensitized peanut-tolerant controls with an adjusted odds ratio of 1.44 per unit EPE (95% CI:1.06-1.94). There was no significant interaction between EPE and FLG loss-of-function mutations, egg sensitization at age 4 years, infantile eczema or parental atopy on peanut sensitization.Conclusions: Higher levels of environmental exposure to peanut in the first few months of life appear to increase the probability of developing school-age peanut sensitization in atopic children (based on egg sensitization and parental atopy).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- BAMSE
- egg sensitization
- environmental peanut exposure
- FLG mutation
- infantile eczema peanut sensitization
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Brough, H. A.
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Kull, I.
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Richards, K.
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Hallner, E.
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Söderhäll, C.
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Douiri, A.
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show more...
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Penagos, M.
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Melen, E.
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Bergström, A.
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Turcanu, V.
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Wickman, Magnus
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Lack, G.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Clinical and Exp ...
- By the university
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Uppsala University
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Karolinska Institutet