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No Benefit of Ticag...
No Benefit of Ticagrelor Pretreatment Compared With Treatment During Percutaneous Coronary Intervention in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
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- Koul, Sasha (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital
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- Gustav Smith, J. (author)
- Karolinska Institutet,Lund University,Lunds universitet,Cardiovascular Epigenetics,Forskargrupper vid Lunds universitet,Lund University Research Groups,Capio St. Görans Sjukhus
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- Götberg, Matthias (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Omerovic, Elmir (author)
- Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden,Sahlgrenska University Hospital
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- Alfredsson, Joakim (author)
- Linköping University,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Venetsanos, Dimitrios (author)
- Linköping University,Linköpings universitet,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
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- Persson, Jonas (author)
- Karolinska Institutet
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- Jensen, Jens (author)
- Capio St Goran Hosp, Karolinska Inst, Dept Med, Stockholm, Sweden
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- Lagerqvist, Bo, 1952- (author)
- Uppsala University,Karolinska Institute,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Redfors, Björn (author)
- Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden,Sahlgrenska University Hospital
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- James, Stefan K, 1964- (author)
- Uppsala University,Karolinska Institute,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinska vetenskaper,Uppsala Univ, Sweden
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- Erlinge, David (author)
- Lund Univ, Skane Univ Hosp Lund, Dept Cardiol, Lund, Sweden;Lund Univ, Skane Univ Hosp Lund, Dept Clin Sci, Lund, Sweden,Skåne University Hospital
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(creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2018
- 2018
- English.
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In: Circulation. Cardiovascular Interventions. - : LIPPINCOTT WILLIAMS & WILKINS. - 1941-7640 .- 1941-7632. ; 11:3
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Abstract
Subject headings
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- Background-The effects of ticagrelor pretreatment in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI) is debated. This study investigated the effects of ticagrelor pretreatment on clinical outcomes in this patient group.Methods and Results-Patients with ST-segment-elevation myocardial infarction undergoing primary PCI were included from October 2010 to October 2014 in Sweden. Screening was done using the SWEDEHEART register (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies). A total of 7433 patients were included for analysis with 5438 patients receiving ticagrelor pretreatment and 1995 patients with ticagrelor given only in the catheterization laboratory. The primary end point of the study was 30-day event rates of a composite of all-cause mortality, myocardial infarction (MI), and stent thrombosis. Secondary end points were mortality, MI, or stent thrombosis alone and major in-hospital bleeding. Crude event rates showed no difference in 30-day composite end point (6.2% versus 6.5%; P=0.69), mortality (4.5% versus 4.7%; P=0.86), MI (1.6% versus 1.7%; P=0.72), or stent thrombosis (0.5% versus 0.4%; P=0.80) with ticagrelor pretreatment. Three different statistical models were used to correct for baseline differences. No difference in the composite end point, mortality, MI, or stent thrombosis was seen between the 2 groups after statistical adjustment. No increase in in-hospital major bleeding rate was observed with ticagrelor pretreatment.Conclusions-Ticagrelor pretreatment versus ticagrelor given in the catheterization laboratory in patients with ST-segment-elevation myocardial infarction undergoing primary PCI did not improve the composite end point of all-cause mortality or MI or stent thrombosis or its individual components at 30 days.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- myocardial infarction
- percutaneous coronary intervention
- ST-elevation myocardial infarction
- stents
- thrombosis
- Myocardial infarction
- Percutaneous coronary intervention
- ST-elevation myocardial infarction
- Stents
- Thrombosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Koul, Sasha
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Gustav Smith, J.
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Götberg, Matthia ...
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Omerovic, Elmir
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Alfredsson, Joak ...
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Venetsanos, Dimi ...
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show more...
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Persson, Jonas
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Jensen, Jens
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Lagerqvist, Bo, ...
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Redfors, Björn
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James, Stefan K, ...
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Erlinge, David
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Circulation. Car ...
- By the university
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Uppsala University
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Linköping University
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Lund University
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Karolinska Institutet