SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-359883"
 

Search: onr:"swepub:oai:DiVA.org:uu-359883" > The asthma-rhinitis...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Siroux, V.Univ Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France (author)

The asthma-rhinitis multimorbidity is associated with IgE polysensitization in adolescents and adults

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-02-06
  • WILEY,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-359883
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-359883URI
  • https://doi.org/10.1111/all.13410DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:138545086URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • BackgroundChildren with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents and adults using defined allergen molecules. We investigated IgE sensitization patterns towards a broad panel of aeroallergen components in adults and adolescents with a focus on individuals with asthma and rhinitis multimorbidity.MethodsIgE reactivity to 64 micro-arrayed aeroallergen molecules was determined with the MeDALL-chip in samples from the French EGEA study (n = 840, age = 40.7 17.1) and the Swedish population-based birth cohort BAMSE (n = 786, age = 16 0.26). The age- and sex-adjusted associations between the number of IgE-reactive allergen molecules (0.3 ISU) and the asthma-rhinitis phenotypes were assessed using a negative binomial model.ResultsGroups representing 4 phenotypes were identified: no asthma-no rhinitis (A-R-; 30% in EGEA and 54% in BAMSE), asthma alone (A+R-; 11% and 8%), rhinitis alone (A-R+; 15% and 24%) and asthma-rhinitis (A+R+; 44% and 14%). The numbers of IgE-reactive aeroallergen molecules significantly differed between phenotypes (median in A-R-, A+R-, A-R+ and A+R+: 0, 1, 2 and 7 in EGEA and 0, 0, 3 and 5 in BAMSE). As compared to A-R- subjects, the adjusted ratio of the mean number of IgE-reactive molecules was higher in A+R+ than in A+R- or A-R+ (10.0, 5.4 and 5.0 in EGEA and 7.2, 0.7 and 4.8 in BAMSE). ConclusionThe A+R+ phenotype combined the sensitization pattern of both the A-R+ and A+R- phenotypes. This multimorbid polysensitized phenotype seems to be generalizable to various ages and allergenic environments and may be associated with specific mechanisms.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ballardini, N.Karolinska Institutet (author)
  • Soler, M.Univ Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France (author)
  • Lupinek, C.Med Univ Vienna, Dept Pathophysiol & Allergy Res, Div Immunopathol, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria (author)
  • Boudier, A.Univ Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France (author)
  • Pin, I.Univ Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France;CHU Grenoble Alpes, Dept Pediat, Grenoble, France (author)
  • Just, J.Children Hosp Armand Trousseau, Allergol Dept, Paris, France;UPMC, INSERM, UMR S 1136, Paris, France (author)
  • Nadif, R.INSERM, U1168, VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Villejuif, France;Univ Versailles St Quentin En Yvelines, UMR S 1168, Montigny Le Bretonneux, France (author)
  • Anto, J. M.Ctr Res Environm Epidemiol CREAL, ISGLoBAL, Barcelona, Spain (author)
  • Melen, E.Karolinska Institutet (author)
  • Valenta, R.Med Univ Vienna, Dept Pathophysiol & Allergy Res, Div Immunopathol, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria;NRC Inst Immunol FMBA Russia, Moscow, Russia (author)
  • Wickman, MagnusUppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Inst Environm Med, Stockholm, Sweden;Soder Sjukhuset, Sachs Children & Youth Hosp, Stockholm, Sweden (author)
  • Bousquet, J.INSERM, U1168, VIMA Aging & Chron Dis Epidemiol & Publ Hlth Appr, Villejuif, France;Univ Versailles St Quentin En Yvelines, UMR S 1168, Montigny Le Bretonneux, France (author)
  • Karolinska InstitutetUniv Grenoble Alpes, IAB, CNRS, INSERM, Grenoble, France (creator_code:org_t)

Related titles

  • In:Allergy. European Journal of Allergy and Clinical Immunology: WILEY73:7, s. 1447-14580105-45381398-9995

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view