Alzheimer's disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Sardar Sinha, Maitrayee (author): Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten

Ansell - Schultz, Anna (author): Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten

Civitelli, Livia (author): Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten

Hildesjö, Camilla, 1969- (author): Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi

Larsson, Max (author): Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten

Lannfelt, Lars (author): Uppsala universitet,Geriatrik,BioArctic AB, Stockholm, Sweden,Uppsala Univ, Sweden; BioArctic AB, Sweden

Ingelsson, Martin (author): Uppsala universitet,Geriatrik,Uppsala Univ, Sweden

Hallbeck, Martin (author): Linköpings universitet,Avdelning för neurobiologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi

(creator_code:org_t)

2018-06-13
2018
English.
In: Acta Neuropathologica. - : SPRINGER. - 0001-6322 .- 1432-0533. ; 136:1, s. 41-56

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Abstract Subject headings

The gradual deterioration of cognitive functions in Alzheimer's disease is paralleled by a hierarchical progression of amyloid-beta and tau brain pathology. Recent findings indicate that toxic oligomers of amyloid-beta may cause propagation of pathology in a prion-like manner, although the underlying mechanisms are incompletely understood. Here we show that small extracellular vesicles, exosomes, from Alzheimer patients' brains contain increased levels of amyloid-beta oligomers and can act as vehicles for the neuron-to-neuron transfer of such toxic species in recipient neurons in culture. Moreover, blocking the formation, secretion or uptake of exosomes was found to reduce both the spread of oligomers and the related toxicity. Taken together, our results imply that exosomes are centrally involved in Alzheimer's disease and that they could serve as targets for development of new diagnostic and therapeutic principles.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)

By the author/editor: Sardar Sinha, Ma ...; Ansell - Schultz ...; Civitelli, Livia; Hildesjö, Camill ...; Larsson, Max; Lannfelt, Lars; show more...; Ingelsson, Marti ...; Hallbeck, Martin; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Neurology

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