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Changes in plasma l...
Changes in plasma levels of perfluoroalkyl substances (PFASs) are related to increase in carotid intima-media thickness over 10 years - a longitudinal study
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- Lind, P. Monica, 1957- (author)
- Uppsala universitet,Arbets- och miljömedicin,Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
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- Salihovic, Samira (author)
- Örebro universitet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Orebro Univ, Sch Sci & Technol, MTM Res Ctr, Orebro, Sweden,Institutionen för naturvetenskap och teknik,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden,MTM Research Centre
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- Stubleski, Jordan, 1990- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre,Orebro Univ, Sch Sci & Technol, MTM Res Ctr, Orebro, Sweden
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- Kärrman, Anna, 1975- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Centre,Orebro Univ, Sch Sci & Technol, MTM Res Ctr, Orebro, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- 2018-07-03
- 2018
- English.
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In: Environmental Health. - : BMC. - 1476-069X. ; 17
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Abstract
Subject headings
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- Background: It has previously been reported that the environmental contaminants perfluoroalkyl substances (PFASs) are linked to atherosclerosis in cross-sectional studies. Since cross-sectional studies could be subject to reverse causation, the purpose of this study was to analyze if the longitudinal changes in PFASs during a 10-year follow-up were related to the change in carotid artery intima-media thickness (IMT, ultrasound) during the same period.Methods: In the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, 1016 individuals were investigated at age 70; 826 of them were reinvestigated at age 75 and 602 at age 80 years. Eight different PFASs were measured in plasma by ultra-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS), and IMT was measured at all three time points. Random-effects mixed regression models were used to examine the associations over time.Results: IMT increased 0.058 mm during the 10-year period (p <0.0001). Following adjustment for baseline values of PFASs (age 70) and sex, the changes in plasma levels of 6 of the 8 measured PFASs were significantly related to the change in IMT over the 10-year follow-up period in a positive fashion (p <0.0062 using Bonferroni correction for 8 tests). Further adjustment for traditional cardiovascular (CV) risk factors (HDL and LDL cholesterol, smoking, systolic blood pressure, statin use, fasting glucose and serum triglycerides) affected these relationships only marginally.Conclusion: The change in plasma levels of several PFASs during 10 years was positively related to increase in IMT seen during the same period, giving prospective evidence that PFASs might interfere with the atherosclerotic process.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- Atherosclerosis
- Longitudinal
- Perfluoroalkyl substances (PFASs)
- Elderly
- Epidemiology
- IMT
Publication and Content Type
- ref (subject category)
- art (subject category)
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