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Antischistosomal Pr...
Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis
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- Kang, Naixin (author)
- Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacognosy, Suzhou 215123, Peoples R China
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- Shen, Wenhua (author)
- Jiangxi Univ Tradit Chinese Med, Coll Pharmaceut Sci, Nanchang 330006, Jiangxi, Peoples R China
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- Gao, Hongwei (author)
- Guangxi Univ Chinese Med, Coll Pharm, Nanning 530001, Peoples R China
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- Feng, Yulin (author)
- Jiangxi Univ Tradit Chinese Med, Coll Pharmaceut Sci, Nanchang 330006, Jiangxi, Peoples R China
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- Zhu, Weifeng (author)
- Jiangxi Univ Tradit Chinese Med, Coll Pharmaceut Sci, Nanchang 330006, Jiangxi, Peoples R China
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- Yang, Shilin (author)
- Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacognosy, Suzhou 215123, Peoples R China;Jiangxi Univ Tradit Chinese Med, Coll Pharmaceut Sci, Nanchang 330006, Jiangxi, Peoples R China
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- Liu, Yanli (author)
- Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacol, Suzhou 215123, Peoples R China
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- Xu, Qiongming (author)
- Soochow Univ, Coll Pharmaceut Sci, Dept Pharmacognosy, Suzhou 215123, Peoples R China
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- Yu, Di, 1985- (author)
- Uppsala universitet,Klinisk immunologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2018-06-13
- 2018
- English.
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In: Molecules. - : MDPI. - 1431-5157 .- 1420-3049. ; 23:6
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Abstract
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- Background: Schistosomiasis is a major neglected disease for which the current control strategy involves mass treatment with praziquantel, the only available drug. Hence, there is an urgent need to develop new antischistosomal compounds.Methods: The antischistosomal activity of hederacolchiside A1 (HSA) were determined by total or female worm burden reductions in mice harboring Schistosoma japonicum or S. mansoni. Pathology parameters were detected on HSA against 1-day-old S. japonicum-harboring mice. Moreover, we confirmed the antischistosomal effect of HSA on newly transformed schistosomula (NTS) of S. japonicum in vitro.Results: HSA, a natural product isolated from Pulsatilla chinensis (Bunge) Regel, was initially corroborated to possess promising antischistosomal properties. We demonstrated that HSA had high activity against S. japonicum and S. mansoni less in 11 days old parasites harbored in mice. The antischistosomal effect was even more than the currently used drugs, praziquantel, and artesunate. Furthermore, HSA could ameliorate the pathology parameters in mice harboring 1-day-old juvenile S. japonicum. We also confirmed that HSA-mediated antischistosomal activity is partly due to the morphological changes in the tegument system when NTS are exposed to HSA.Conclusions: HSA may have great potential to be an antischistosomal agent for further research.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- hederacolchiside A1
- Schistosoma japonicum
- Schistosoma mansoni
- antischistosomal
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kang, Naixin
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Shen, Wenhua
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Gao, Hongwei
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Feng, Yulin
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Zhu, Weifeng
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Yang, Shilin
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show more...
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Liu, Yanli
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Xu, Qiongming
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Yu, Di, 1985-
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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Molecules
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Uppsala University