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Noelin1 Affects Lat...
Noelin1 Affects Lateral Mobility of Synaptic AMPA Receptors
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- Pandya, Nikhil J (author)
- Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands
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- Seeger, Christian, 1982- (author)
- Uppsala universitet,Biokemi,Beactica AB, Uppsala, Sweden
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- Babai, Norbert (author)
- Friedrich Alexander Univ Erlangen Nurnberg, Dept Biol, Anim Physiol, Erlangen, Germany
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- Gonzalez-Lozano, Miguel A (author)
- Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands
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- Mack, Volker (author)
- Boehringer Ingelheim Pharma GmbH & Co KG, Dept CNS Dis Res, Biberach, Germany
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- Lodder, Johannes C (author)
- Vrije Univ Amsterdam, Dept Integrat Neurophysiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Boelelaan, Amsterdam, Netherlands
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- Gouwenberg, Yvonne (author)
- Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands
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- Mansvelder, Huibert D. (author)
- Vrije Univ Amsterdam, Dept Integrat Neurophysiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Boelelaan, Amsterdam, Netherlands
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- Danielson, U. Helena, Professor, 1959- (author)
- Uppsala universitet,Biokemi,Beactica AB, Uppsala, Sweden
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- Li, Ka Wan (author)
- Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands
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- Heine, Martin (author)
- Leibniz Inst Neurobiol, Res Grp Mol Physiol, Magdeburg, Germany
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- Spijker, Sabine (author)
- Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands
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- Frischknecht, Renato (author)
- Friedrich Alexander Univ Erlangen Nurnberg, Dept Biol, Anim Physiol, Erlangen, Germany; Leibniz Inst Neurobiol, Dept Neurochem & Mol Biol, Magdeburg, Germany
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- Smit, August B. (author)
- Vrije Univ Amsterdam, Dept Mol & Cellular Neurobiol, Ctr Neurogen & Cognit Res, Amsterdam Neurosci, Amsterdam, Netherlands
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(creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
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In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 24:5, s. 1218-1230
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Abstract
Subject headings
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- Lateral diffusion on the neuronal plasma membrane of the AMPA-type glutamate receptor (AMPAR) serves an important role in synaptic plasticity. We investigated the role of the secreted glycoprotein Noelin1 (Olfactomedin-1 or Pancortin) in AMPAR lateral mobility and its dependence on the extracellular matrix (ECM). We found that Noelin1 interacts with the AMPAR with high affinity, however, without affecting rise- and decay time and desensitization properties. Noelin1 co-localizes with synaptic and extra-synaptic AMPARs and is expressed at synapses in an activity-dependent manner. Single-particle tracking shows that Noelin1 reduces lateral mobility of both synaptic and extra-synaptic GluA1-containing receptors and affects short-term plasticity. While the ECM does not constrain the synaptic pool of AMPARs and acts only extrasynaptically, Noelin1 contributes to synaptic potentiation by limiting AMPAR mobility at synaptic sites. This is the first evidence for the role of a secreted AMPAR-interacting protein on mobility of GluA1-containing receptors and synaptic plasticity.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- AMPAR-associated protein
- glutamate receptor
- receptor mobility
- synapse function
- synaptic plasticity
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pandya, Nikhil J
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Seeger, Christia ...
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Babai, Norbert
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Gonzalez-Lozano, ...
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Mack, Volker
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Lodder, Johannes ...
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show more...
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Gouwenberg, Yvon ...
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Mansvelder, Huib ...
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Danielson, U. He ...
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Li, Ka Wan
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Heine, Martin
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Spijker, Sabine
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Frischknecht, Re ...
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Smit, August B.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmacology and ...
- Articles in the publication
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Cell Reports
- By the university
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Uppsala University