Auditory brainstem response (ABR) profiling tests as diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD)

Objective: To evaluate the performances of two auditory brainstem response (ABR) profiling tests as potential biomarkers and diagnostic support for schizophrenia and adult attention-deficit hyperactivity disorder (ADHD), respectively, in an investigator-initiated blinded study design.Method: Male and female patients with schizophrenia (n=26) and adult ADHD (n=24) meeting Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM IV) diagnostic criteria and healthy controls (n=58) comprised the analysis set (n=108) of the total number of study participants (n=119). Coded sets of randomized ABR recordings were analysed by an independent party blinded to clinical diagnoses before a joint code-breaking session.Results: The ABR profiling test for schizophrenia identified schizophrenia patients versus controls with a sensitivity of 84.6% and a specificity of 93.1%. The ADHD test identified patients with adult ADHD versus controls with a sensitivity of 87.5% and a specificity of 91.4%.Conclusion: The ABR profiling tests discriminated schizophrenia and ADHD versus healthy controls with high sensitivity and specificity. The methods deserve to be further explored in larger clinical studies including a broad range of psychiatric disorders to determine their utility as potential diagnostic biomarkers.

Nilsson, Maria MarkhedUppsala universitet,Psykiatri, Akademiska sjukhuset(Swepub:uu)marni511 (author)
Lindström, EvaUppsala universitet,Psykiatri, Akademiska sjukhuset(Swepub:uu)evlin676 (author)
Nilsson, Björn M.Uppsala universitet,Psykiatri, Akademiska sjukhuset(Swepub:uu)bjornilss (author)
Lewander, TommyUppsala universitet,Psykiatri, Akademiska sjukhuset(Swepub:uu)tommlewa (author)
Uppsala universitetPsykiatri, Akademiska sjukhuset (creator_code:org_t)

In:Acta Neuropsychiatrica: Cambridge University Press (CUP)30:3, s. 137-1470924-27081601-5215

By the author/editor: Baghdassarian, E ...; Nilsson, Maria M ...; Lindström, Eva; Nilsson, Björn M ...; Lewander, Tommy

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

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