onr:"swepub:oai:DiVA.org:uu-362194"
Search: onr:"swepub:oai:DiVA.org:uu-362194" > Nicotinic receptor ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Nicotinic receptor abnormalities as a biomarker in idiopathic generalized epilepsy
-
- Garibotto, Valentina (author)
- Univ Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland; Univ Geneva, Fac Med, Geneva, Switzerland
-
- Wissmeyer, Michael (author)
- Univ Hosp Geneva, Nucl Med & Mol Imaging Div, Dept Med Imaging, Geneva, Switzerland
-
- Giavri, Zoi (author)
- Advantis Med Imaging, Eindhoven, Netherlands
- show more...
- show less...
- (creator_code:org_t)
- 2018-09-29
- 2019
- English.
- In: European Journal of Nuclear Medicine and Molecular Imaging. - : Springer Science and Business Media LLC. - 1619-7070 .- 1619-7089. ; 46:2, s. 385-395
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Purpose: Mutations of cholinergic neuronal nicotinic receptors have been identified in the autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE), associated with changes on PET images using [18F]-F-85380-A (F-A-85380), an α4β2 nicotinic receptor ligand. The aim of the present study was to evaluate potential changes in nicotinic receptor availability in other types of epilepsy.Methods: We included 34 male participants, 12 patients with idiopathic generalized epilepsy (IGE), 10 with non-lesional diurnal focal epilepsy, and 12 age-matched healthy controls. All patients underwent PET/CT using F-A-85380 and [18F]-fluorodeoxyglucose (FDG), 3D T1 MRI and diffusion tensor imaging (DTI). F-A-85380 and FDG images were compared with the control group using a voxel-wise (SPM12) and a volumes of interest (VOI) analysis.Results: In the group of patients with IGE, the voxel-wise and VOI analyses showed a significant increase of F-A-85380 ratio index of binding potential (BPRI, corresponding to the receptor availability) in the anterior cingulate cortex (ACC), without structural changes on MRI. At an individual level, F-A-85380 BPRI increase in the ACC could distinguish IGE patients from controls and from patients with focal epilepsy with good accuracy.Conclusions: We observed focal changes of density/availability of nicotinic receptors in IGE, namely an increase in the ACC. These data suggest that the modulation of α4β2 nicotinic receptors plays a role not only in ADNFLE, but also in other genetic epileptic syndromes such as IGE and could serve as a biomarker of epilepsy syndromes with a genetic background.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- F-A-85380
- Focal epilepsy
- Idiopathic generalized epilepsy
- Nicotinic receptors
- PET
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- European Journal of Nuclear Medicine and Molecular Imaging (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Garibotto, Valen ...
- Wissmeyer, Micha ...
- Giavri, Zoi
- Goldstein, Rache ...
- Seimbille, Yann
- Seeck, Margitta
- show more...
- Ratib, Osman
- Haller, Sven
- Picard, Fabienne
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Radiology Nuclea ...
- Articles in the publication
- European Journal ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
