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Sensitization to mi...
Sensitization to minor cat allergen components is associated with type-2 biomarkers in young asthmatics
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- Tsolakis, Nikolaos (author)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Malinovschi, Andrei, 1978- (author)
- Uppsala universitet,Klinisk fysiologi
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- Nordvall, Lennart (author)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Mattsson, Lars (author)
- Thermo Fisher Sci, Uppsala, Sweden
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- Lidholm, Jonas (author)
- Thermo Fisher Scientific, Uppsala, Sweden
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- Pedroletti, C. (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Janson, Christer (author)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Borres, Magnus P, 1956- (author)
- Uppsala universitet,Pediatrisk inflammationsforskning
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- Alving, Kjell, 1959- (author)
- Uppsala universitet,Pediatrisk inflammationsforskning
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(creator_code:org_t)
- 2018-04-19
- 2018
- English.
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In: Clinical and Experimental Allergy. - : Wiley. - 0954-7894 .- 1365-2222. ; 48:9, s. 1186-1194
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background: Cat allergy is a major trigger of asthma world-wide. Molecular patterns of cat sensitization vary between individuals, but their relationship to inflammation in asthmatics has not been extensively studied.Objective: To investigate the prevalence and levels of IgE antibodies against different cat allergen components and their relationship to type-2 inflammation and total IgE among young asthmatic subjects sensitized to furry animals.Methods: Patients with asthma (age 10-35 years; n = 266) and IgE sensitization to cat, dog or horse extract (ImmunoCAP), were analysed for IgE to the cat allergen components Fel d 1 (secretoglobin), Fel d 2 (serum albumin), Fel d 4 and Fel d 7 (lipocalins). Independent associations between IgE-antibody concentrations, and fraction of exhaled nitric oxide (FeNO), blood eosinophil (B-Eos) count, and total IgE were analysed by multiple linear regression after adjustment for possible confounders.Results: The level of IgE against Fel d 2 was independently related to FeNO (P = .012) and total IgE (P < .001), and IgE against Fel d 4 associated with B-Eos count (P = .009) and total IgE (P < .001). IgE antibodies against Fel d 1 or cat extract did not independently relate to these inflammatory markers (P = .23-.51).Conclusions: Levels of IgE to lipocalin (Fel d 4) and serum albumin (Fel d 2), but not to secretoglobin (Fel d 1) or cat extract, were independently associated with type-2 biomarkers and total IgE in young asthmatics.Clinical relevance: We suggest that measurement of IgE to minor cat allergen components may be useful when investigating asthma morbidity in cat allergic subjects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- asthma
- clinical immunology
- eosinophils
- IgE
- immunologic tests
Publication and Content Type
- ref (subject category)
- art (subject category)
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Tsolakis, Nikola ...
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Malinovschi, And ...
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Nordvall, Lennar ...
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Mattsson, Lars
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Lidholm, Jonas
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Pedroletti, C.
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Janson, Christer
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Borres, Magnus P ...
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Alving, Kjell, 1 ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
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Clinical and Exp ...
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Uppsala University