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Editor's Choice-Wha...
Editor's Choice-What to do when you question cardiac troponin values
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- Mair, Johannes (author)
- Med Univ Innsbruck, Heart Ctr, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria
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- Lindahl, Bertil, 1957- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Müller, Christian (author)
- Univ Basel Hosp, Dept Cardiol, Basel, Switzerland; Univ Basel Hosp, Cardiovasc Res Inst Basel, Basel, Switzerland
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- Giannitsis, Evangelos (author)
- Heidelberg Univ, Dept Cardiol, Med Klin 3, Heidelberg, Germany
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- Huber, Kurt (author)
- Wilhelminen Hosp, Dept Med Cardiol & Intens Care Med, Vienna, Austria
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- Möckel, Martin (author)
- Charite Univ Med Berlin, Div Emergency Med, Berlin, Germany; Charite Univ Med Berlin, Dept Cardiol, Berlin, Germany
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- Plebani, Mario (author)
- Univ Hosp Padova, Dept Lab Med, Padua, Italy
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- Thygesen, Kristian (author)
- Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark
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- Jaffe, Allan S. (author)
- Mayo Clin & Mayo Grad Sch Med, Rochester, MN USA
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(creator_code:org_t)
- 2017-05-09
- 2018
- English.
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In: European Heart Journal. - : SAGE PUBLICATIONS LTD. - 2048-8726 .- 2048-8734. ; 7:6, s. 577-586
- Related links:
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https://journals.sag...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- High-sensitivity cardiac troponin assays enable cardiac troponin measurement with a high degree of analytical sensitivity and a low level of analytical imprecision at the low measuring range. One of the most important advantages of these new assays is that they allow novel, more rapid approaches for ruling in or ruling out acute myocardial infarctions. The increase in the early diagnostic sensitivity of high-sensitivity cardiac troponin assays comes at the cost of a reduced acute myocardial infarction specificity of the biomarker, because more patients with other causes of acute or chronic myocardial injury without overt myocardial ischaemia are detected than with previous cardiac troponin assays. Increased troponin concentrations that do not fit with the clinical presentation are seen in the daily routine, mainly as a result of a variety of pathologies, and if tested in the same sample, even discrepancies between high-sensitivity cardiac troponin I and troponin T test results may sometimes be found as well. In addition, analytically false-positive test results occasionally may occur since no assay is perfect. In this review, we summarise the biochemical, pathophysiological and analytical background of the work-up for such a clinical setting.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Cardiac troponin I
- cardiac troponin T
- high sensitivity
- discrepancy
- interference
- mismatch
Publication and Content Type
- ref (subject category)
- art (subject category)
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Mair, Johannes
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Lindahl, Bertil, ...
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Müller, Christia ...
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Giannitsis, Evan ...
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Huber, Kurt
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Möckel, Martin
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Plebani, Mario
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Thygesen, Kristi ...
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Jaffe, Allan S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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European Heart J ...
- By the university
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Uppsala University