Molecular allergy diagnostics refine characterization of children sensitized to dog dander

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Molecular allergy diagnostics refine characterization of children sensitized to dog dander

Käck, Ulrika (author): Karolinska Institutet

Asarnoj, Anna (author): Karolinska Institutet

Grönlund, Hans (author): Karolinska Institutet

Borres, Magnus P, 1956- (author): Uppsala universitet,Pediatrisk inflammationsforskning,Thermo Fisher Sci, Uppsala, Sweden

van Hage, Marianne (author): Karolinska Institutet

Lilja, Gunnar (author): Karolinska Institutet

Konradsen, Jon R. (author): Karolinska Institutet

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(creator_code:org_t)

MOSBY-ELSEVIER, 2018
2018
English.
In: Journal of Allergy and Clinical Immunology. - : MOSBY-ELSEVIER. - 0091-6749 .- 1097-6825. ; 142:4, s. 1113-

Related links:: http://www.jacionlin...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Sensitization to dog dander is an important risk factor for rhinoconjunctivitis and asthma but is not sufficient for diagnosing dog allergy. Molecular allergy diagnostics offer new opportunities for refined characterization. Objectives: We sought to study the association between sensitization to all presently known dog allergen components and clinical symptoms of dog allergy in children evaluated by using nasal provocation tests (NPTs). Methods: Sixty children (age, 10-18 years) sensitized to dog dander extract underwent NPTs with dog dander extract. Measurement of IgE levels to dog dander and to Can f 1, Can f 2, Can f 3, and Can f 5 was performed with ImmunoCAP, and measurement of IgE levels to Can f 4 and Can f 6 was performed with streptavidin ImmunoCAP. An IgE level of 0.1 kU(A)/L or greater was considered positive. Results: There was an association between sensitization to an increasing number of dog allergen components and a positive nasal challenge result (P = .01). Sensitization to lipocalins (odds ratio [OR], 6.0; 95% CI, 1.04-34.5), in particular Can f 4 (OR, 6.80; 95% CI 1.84-25.2) and Can f 6 (OR, 5.69; 95% CI, 1.59-20.8), was associated with a positive NPT result. Monosensitization to Can f 5 was related to a negative NPT result (OR, 5.78; 95% CI, 1.01-33.0). Conclusion: Sensitization to an increasing number of dog allergen components and to lipocalins is associated with dog allergy. Monosensitization to Can f 5 should not be regarded primarily as a marker for dog allergy.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)

Keyword

Allergy
Can f 1
Can f 2
Can f 3
Can f 4
Can f 5
Can f 6
children
dog
IgE
molecular allergology
nasal provocation test
sensitization

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ref (subject category)
art (subject category)

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By the author/editor: Käck, Ulrika; Asarnoj, Anna; Grönlund, Hans; Borres, Magnus P ...; van Hage, Marian ...; Lilja, Gunnar; show more...; Konradsen, Jon R ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

Articles in the publication: Journal of Aller ...

By the university: Uppsala University; Karolinska Institutet

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