A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.

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Fältnamn	Indikatorer	Metadata
000		09824naa a2202137 4500
001		oai:DiVA.org:uu-368161
003		SwePub
008		181204s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:139155293
009		oai:lup.lub.lu.se:f5ad9bbb-4e84-4d66-b5a5-fa964353cbb6
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3681612 URI
024	7	a https://doi.org/10.1158/0008-5472.CAN-18-09512 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1391552932 URI
024	7	a https://lup.lub.lu.se/record/f5ad9bbb-4e84-4d66-b5a5-fa964353cbb62 URI
040		a (SwePub)uud (SwePub)kid (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Lu, Yingchangu Vanderbilt University4 aut
245	1 0	a A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk.
264	1	c 2018
338		a print2 rdacarrier
520		a .AbstractLarge-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal genes underlying these associations remain largely unknown. Here, we performed a transcriptome-wide association study to search for novel genetic loci and plausible causal genes at known GWAS loci. We used RNA sequencing data (68 normal ovarian tissue samples from 68 individuals and 6,124 cross-tissue samples from 369 individuals) and high-density genotyping data from European descendants of the Genotype-Tissue Expression (GTEx V6) project to build ovarian and cross-tissue models of genetically regulated expression using elastic net methods. We evaluated 17,121 genes for their cis-predicted gene expression in relation to EOC risk using summary statistics data from GWAS of 97,898 women, including 29,396 EOC cases. With a Bonferroni-corrected significance level of P < 2.2 × 10−6, we identified 35 genes, including FZD4 at 11q14.2 (Z = 5.08, P = 3.83 × 10−7, the cross-tissue model; 1 Mb away from any GWAS-identified EOC risk variant), a potential novel locus for EOC risk. All other 34 significantly associated genes were located within 1 Mb of known GWAS-identified loci, including 23 genes at 6 loci not previously linked to EOC risk. Upon conditioning on nearby known EOC GWAS-identified variants, the associations for 31 genes disappeared and three genes remained (P < 1.47 × 10−3). These data identify one novel locus (FZD4) and 34 genes at 13 known EOC risk loci associated with EOC risk, providing new insights into EOC carcinogenesis.Significance: Transcriptomic analysis of a large cohort confirms earlier GWAS loci and reveals FZD4 as a novel locus associated with EOC risk. Cancer Res; 78(18); 5419–30. ©2018 AACR.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Beeghly-Fadiel, Alicia4 aut
700	1	a Wu, Lang4 aut
700	1	a Guo, Xingyi4 aut
700	1	a Li, Bingshan4 aut
700	1	a Schildkraut, Joellen M4 aut
700	1	a Im, Hae Kyung4 aut
700	1	a Chen, Yian A4 aut
700	1	a Permuth, Jennifer B4 aut
700	1	a Reid, Brett M4 aut
700	1	a Teer, Jamie K4 aut
700	1	a Moysich, Kirsten B4 aut
700	1	a Andrulis, Irene L4 aut
700	1	a Anton-Culver, Hoda4 aut
700	1	a Arun, Banu K4 aut
700	1	a Bandera, Elisa V4 aut
700	1	a Barkardottir, Rosa B4 aut
700	1	a Barnes, Daniel R4 aut
700	1	a Benitez, Javier4 aut
700	1	a Bjorge, Line4 aut
700	1	a Brenton, James4 aut
700	1	a Butzow, Ralf4 aut
700	1	a Caldes, Trinidad4 aut
700	1	a Caligo, Maria A4 aut
700	1	a Campbell, Ian4 aut
700	1	a Chang-Claude, Jenny4 aut
700	1	a Claes, Kathleen B M4 aut
700	1	a Couch, Fergus J4 aut
700	1	a Cramer, Daniel W4 aut
700	1	a Daly, Mary B4 aut
700	1	a deFazio, Anna4 aut
700	1	a Dennis, Joe4 aut
700	1	a Diez, Orland4 aut
700	1	a Domchek, Susan M4 aut
700	1	a Dörk, Thilo4 aut
700	1	a Easton, Douglas F4 aut
700	1	a Eccles, Diana M4 aut
700	1	a Fasching, Peter A4 aut
700	1	a Fortner, Renée T4 aut
700	1	a Fountzilas, George4 aut
700	1	a Friedman, Eitan4 aut
700	1	a Ganz, Patricia A4 aut
700	1	a Garber, Judy4 aut
700	1	a Giles, Graham G4 aut
700	1	a Godwin, Andrew K4 aut
700	1	a Goldgar, David E4 aut
700	1	a Goodman, Marc T4 aut
700	1	a Greene, Mark H4 aut
700	1	a Gronwald, Jacek4 aut
700	1	a Hamann, Ute4 aut
700	1	a Heitz, Florian4 aut
700	1	a Hildebrandt, Michelle A T4 aut
700	1	a Høgdall, Claus K4 aut
700	1	a Hollestelle, Antoinette4 aut
700	1	a Hulick, Peter J4 aut
700	1	a Huntsman, David G4 aut
700	1	a Imyanitov, Evgeny N4 aut
700	1	a Isaacs, Claudine4 aut
700	1	a Jakubowska, Anna4 aut
700	1	a James, Paul4 aut
700	1	a Karlan, Beth Y4 aut
700	1	a Kelemen, Linda E4 aut
700	1	a Kiemeney, Lambertus A4 aut
700	1	a Kjaer, Susanne K4 aut
700	1	a Kwong, Ava4 aut
700	1	a Le, Nhu D4 aut
700	1	a Leslie, Goska4 aut
700	1	a Lesueur, Fabienne4 aut
700	1	a Levine, Douglas A4 aut
700	1	a Mattiello, Amalia4 aut
700	1	a May, Taymaa4 aut
700	1	a McGuffog, Lesley4 aut
700	1	a McNeish, Iain A4 aut
700	1	a Merritt, Melissa A4 aut
700	1	a Modugno, Francesmary4 aut
700	1	a Montagna, Marco4 aut
700	1	a Neuhausen, Susan L4 aut
700	1	a Nevanlinna, Heli4 aut
700	1	a Nielsen, Finn C4 aut
700	1	a Nikitina-Zake, Liene4 aut
700	1	a Nussbaum, Robert L4 aut
700	1	a Offit, Kenneth4 aut
700	1	a Olah, Edith4 aut
700	1	a Olopade, Olufunmilayo I4 aut
700	1	a Olsson, Håkanu Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups4 aut0 (Swepub:lu)onk-hol
700	1	a Olsson, Håkan4 aut
700	1	a Osorio, Ana4 aut
700	1	a Park, Sue K4 aut
700	1	a Parsons, Michael T4 aut
700	1	a Peeters, Petra H M4 aut
700	1	a Pejovic, Tanja4 aut
700	1	a Peterlongo, Paolo4 aut
700	1	a Phelan, Catherine M4 aut
700	1	a Pujana, Miquel Angel4 aut
700	1	a Ramus, Susan J4 aut
700	1	a Rennert, Gad4 aut
700	1	a Risch, Harvey4 aut
700	1	a Rodriguez, Gustavo C4 aut
700	1	a Rodríguez-Antona, Cristina4 aut
700	1	a Romieu, Isabelle4 aut
700	1	a Rookus, Matti A4 aut
700	1	a Rossing, Mary Anne4 aut
700	1	a Rzepecka, Iwona K4 aut
700	1	a Sandler, Dale P4 aut
700	1	a Schmutzler, Rita K4 aut
700	1	a Setiawan, Veronica W4 aut
700	1	a Sharma, Priyanka4 aut
700	1	a Sieh, Weiva4 aut
700	1	a Simard, Jacques4 aut
700	1	a Singer, Christian F4 aut
700	1	a Song, Honglin4 aut
700	1	a Southey, Melissa C4 aut
700	1	a Spurdle, Amanda B4 aut
700	1	a Sutphen, Rebecca4 aut
700	1	a Swerdlow, Anthony J4 aut
700	1	a Teixeira, Manuel R4 aut
700	1	a Teo, Soo H4 aut
700	1	a Thomassen, Mads4 aut
700	1	a Tischkowitz, Marc4 aut
700	1	a Toland, Amanda E4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Tung, Nadine4 aut
700	1	a Tworoger, Shelley S4 aut
700	1	a van Rensburg, Elizabeth J4 aut
700	1	a Vanderstichele, Adriaan4 aut
700	1	a Vega, Ana4 aut
700	1	a Edwards, Digna Velez4 aut
700	1	a Webb, Penelope M4 aut
700	1	a Weitzel, Jeffrey N4 aut
700	1	a Wentzensen, Nicolas4 aut
700	1	a White, Emily4 aut
700	1	a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)alwol516
700	1	a Wu, Anna H4 aut
700	1	a Yannoukakos, Drakoulis4 aut
700	1	a Zorn, Kristin K4 aut
700	1	a Gayther, Simon A4 aut
700	1	a Antoniou, Antonis C4 aut
700	1	a Berchuck, Andrew4 aut
700	1	a Goode, Ellen L4 aut
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Sellers, Thomas A4 aut
700	1	a Pharoah, Paul D P4 aut
700	1	a Zheng, Wei4 aut
700	1	a Long, Jirongu Vanderbilt University4 aut
710	2	a Vanderbilt Universityb Lunds Melanomstudiegrupp4 org
710	2	a et al.
773	0	t Cancer Researchg 78:18, s. 5419-5430q 78:18<5419-5430x 0008-5472x 1538-7445
856	4	u http://dx.doi.org/10.1158/0008-5472.CAN-18-0951y FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-368161
856	4 8	u https://doi.org/10.1158/0008-5472.CAN-18-0951
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:139155293
856	4 8	u https://lup.lub.lu.se/record/f5ad9bbb-4e84-4d66-b5a5-fa964353cbb6

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By the author/editor: Lu, Yingchang; Beeghly-Fadiel, ...; Wu, Lang; Guo, Xingyi; Li, Bingshan; Schildkraut, Joe ...; show more...; Im, Hae Kyung; Chen, Yian A; Permuth, Jennife ...; Reid, Brett M; Teer, Jamie K; Moysich, Kirsten ...; Andrulis, Irene ...; Anton-Culver, Ho ...; Arun, Banu K; Bandera, Elisa V; Barkardottir, Ro ...; Barnes, Daniel R; Benitez, Javier; Bjorge, Line; Brenton, James; Butzow, Ralf; Caldes, Trinidad; Caligo, Maria A; Campbell, Ian; Chang-Claude, Je ...; Claes, Kathleen ...; Couch, Fergus J; Cramer, Daniel W; Daly, Mary B; deFazio, Anna; Dennis, Joe; Diez, Orland; Domchek, Susan M; Dörk, Thilo; Easton, Douglas ...; Eccles, Diana M; Fasching, Peter ...; Fortner, Renée T; Fountzilas, Geor ...; Friedman, Eitan; Ganz, Patricia A; Garber, Judy; Giles, Graham G; Godwin, Andrew K; Goldgar, David E; Goodman, Marc T; Greene, Mark H; Gronwald, Jacek; Hamann, Ute; Heitz, Florian; Hildebrandt, Mic ...; Høgdall, Claus K; Hollestelle, Ant ...; Hulick, Peter J; Huntsman, David ...; Imyanitov, Evgen ...; Isaacs, Claudine; Jakubowska, Anna; James, Paul; Karlan, Beth Y; Kelemen, Linda E; Kiemeney, Lamber ...; Kjaer, Susanne K; Kwong, Ava; Le, Nhu D; Leslie, Goska; Lesueur, Fabienn ...; Levine, Douglas ...; Mattiello, Amali ...; May, Taymaa; McGuffog, Lesley; McNeish, Iain A; Merritt, Melissa ...; Modugno, Frances ...; Montagna, Marco; Neuhausen, Susan ...; Nevanlinna, Heli; Nielsen, Finn C; Nikitina-Zake, L ...; Nussbaum, Robert ...; Offit, Kenneth; Olah, Edith; Olopade, Olufunm ...; Olsson, Håkan; Osorio, Ana; Park, Sue K; Parsons, Michael ...; Peeters, Petra H ...; Pejovic, Tanja; Peterlongo, Paol ...; Phelan, Catherin ...; Pujana, Miquel A ...; Ramus, Susan J; Rennert, Gad; Risch, Harvey; Rodriguez, Gusta ...; Rodríguez-Antona ...; Romieu, Isabelle; Rookus, Matti A; Rossing, Mary An ...; Rzepecka, Iwona ...; Sandler, Dale P; Schmutzler, Rita ...; Setiawan, Veroni ...; Sharma, Priyanka; Sieh, Weiva; Simard, Jacques; Singer, Christia ...; Song, Honglin; Southey, Melissa ...; Spurdle, Amanda ...; Sutphen, Rebecca; Swerdlow, Anthon ...; Teixeira, Manuel ...; Teo, Soo H; Thomassen, Mads; Tischkowitz, Mar ...; Toland, Amanda E; Trichopoulou, An ...; Tung, Nadine; Tworoger, Shelle ...; van Rensburg, El ...; Vanderstichele, ...; Vega, Ana; Edwards, Digna V ...; Webb, Penelope M; Weitzel, Jeffrey ...; Wentzensen, Nico ...; White, Emily; Wolk, Alicja; Wu, Anna H; Yannoukakos, Dra ...; Zorn, Kristin K; Gayther, Simon A; Antoniou, Antoni ...; Berchuck, Andrew; Goode, Ellen L; Chenevix-Trench, ...; Sellers, Thomas ...; Pharoah, Paul D ...; Zheng, Wei; Long, Jirong; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Surgery

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Medical Genetics

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